Study of anxiolytic activity and possible side effects of the dipeptide ligand of the translocator protein TSPO — compound GD-102 in a wide range of doses in behavioral experiments using rats and mice

Study of anxiolytic activity and possible side effects of the dipeptide ligand of the translocator protein TSPO — compound GD-102 in a wide range of doses in behavioral experiments using rats and mice

Background. The dipeptide TSPO ligand, the compound amide N-phenylpropionyl-L-tryptophanyl-L-leucine (GD-102) was designed and synthesized in the Federal research center for innovator and emerging biomedical and pharmaceutical technologies. It was shown that GD-102 possessed anxiolytic and antidepre...

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Bibliographic Details
Main Authors: S. O. Kotel'nikova, O. A. Deeva, V. A. Kraineva, T. A. Gudasheva, T. A. Voronina, V. L. Dorofeev
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2025-05-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
tspo ligands
gd-102
anxiolytic activity
locomotor activity
myorelaxant effect
mice
rats
Online Access:https://www.pharmacokinetica.ru/jour/article/view/447
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