ProgModule: A novel computational framework to identify mutation driver modules for predicting cancer prognosis and immunotherapy response

Abstract Background Cancer originates from dysregulated cell proliferation driven by driver gene mutations. Despite numerous algorithms developed to identify genomic mutational signatures, they often suffer from high computational complexity and limited clinical applicability. Methods Here, we prese...

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Bibliographic Details
Main Authors: Xiangmei Li, Bingyue Pan, Xilong Zhao, Yinchun Su, Jiyin Lai, Siyuan Li, Yalan He, Jiashuo Wu, Junwei Han
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-025-06497-0
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