The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors
Surface plasmon resonance (SPR) detection technology is playing an important role in various fields such as food safety and environmental monitoring due to its excellent stability and reliability. However, there is also a growing demand for higher sensitivity in SPR sensors. Therefore, this work dev...
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2025-06-01
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| author | Jing Ouyang Xiantong Yu Mengjie Wang Longfei Wang Zhao Li Chaojun Shi Hao Li Yufeng Yuan Jun Zhou Min Chang |
| author_facet | Jing Ouyang Xiantong Yu Mengjie Wang Longfei Wang Zhao Li Chaojun Shi Hao Li Yufeng Yuan Jun Zhou Min Chang |
| author_sort | Jing Ouyang |
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| description | Surface plasmon resonance (SPR) detection technology is playing an important role in various fields such as food safety and environmental monitoring due to its excellent stability and reliability. However, there is also a growing demand for higher sensitivity in SPR sensors. Therefore, this work developed an SPR sensor based on the synergistic effect of electric-field enhancement and adsorption enhancement by using amino acid-derived carbon dots (CDs). The results showed that the incorporation of amino acid CDs can generate a maximum electric-field enhancement of up to 6.44 × 10<sup>5</sup> V/m in the near-field region, which is 312% of that achieved by a bare gold film. And the adsorption kinetics results indicate that the active groups on the surface of amino acid CDs exhibit a notable adsorption enhancement effect for the target molecule (NaCl), with an adsorption capacity 335% higher than that of the bare gold film. This designed SPR sensor demonstrates a detection sensitivity of 167.28 a.u./RIU for NaCl solution, representing a 247.8% improvement compared to an SPR sensor without amino acid CDs under the same conditions. This SPR sensor shows promising potential for applications in biomedical and environmental detection fields. |
| format | Article |
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| institution | OA Journals |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-5707806d9ec24a0e933c6f722bb9674f2025-08-20T02:36:31ZengMDPI AGSensors1424-82202025-06-012513390310.3390/s25133903The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR SensorsJing Ouyang0Xiantong Yu1Mengjie Wang2Longfei Wang3Zhao Li4Chaojun Shi5Hao Li6Yufeng Yuan7Jun Zhou8Min Chang9Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaJiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology, Agricultural College of Yangzhou University, Yangzhou 225009, ChinaSchool of Electronic Engineering and Intelligentization, Dongguan University of Technology, Dongguan 523808, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSurface plasmon resonance (SPR) detection technology is playing an important role in various fields such as food safety and environmental monitoring due to its excellent stability and reliability. However, there is also a growing demand for higher sensitivity in SPR sensors. Therefore, this work developed an SPR sensor based on the synergistic effect of electric-field enhancement and adsorption enhancement by using amino acid-derived carbon dots (CDs). The results showed that the incorporation of amino acid CDs can generate a maximum electric-field enhancement of up to 6.44 × 10<sup>5</sup> V/m in the near-field region, which is 312% of that achieved by a bare gold film. And the adsorption kinetics results indicate that the active groups on the surface of amino acid CDs exhibit a notable adsorption enhancement effect for the target molecule (NaCl), with an adsorption capacity 335% higher than that of the bare gold film. This designed SPR sensor demonstrates a detection sensitivity of 167.28 a.u./RIU for NaCl solution, representing a 247.8% improvement compared to an SPR sensor without amino acid CDs under the same conditions. This SPR sensor shows promising potential for applications in biomedical and environmental detection fields.https://www.mdpi.com/1424-8220/25/13/3903surface plasmon resonance (SPR) sensoramino acid-derived carbon dots (CDs)adsorption kinetics |
| spellingShingle | Jing Ouyang Xiantong Yu Mengjie Wang Longfei Wang Zhao Li Chaojun Shi Hao Li Yufeng Yuan Jun Zhou Min Chang The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors Sensors surface plasmon resonance (SPR) sensor amino acid-derived carbon dots (CDs) adsorption kinetics |
| title | The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors |
| title_full | The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors |
| title_fullStr | The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors |
| title_full_unstemmed | The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors |
| title_short | The Synergistic Effect of Electric-Field and Adsorption Enhancement of Amino Acid Carbon Dots Significantly Improves the Detection Sensitivity of SPR Sensors |
| title_sort | synergistic effect of electric field and adsorption enhancement of amino acid carbon dots significantly improves the detection sensitivity of spr sensors |
| topic | surface plasmon resonance (SPR) sensor amino acid-derived carbon dots (CDs) adsorption kinetics |
| url | https://www.mdpi.com/1424-8220/25/13/3903 |
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