Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions
Dental caries is a widespread issue impacting global oral health. White spot lesions, the earliest stage of caries, compromise enamel’s esthetics and integrity. Remineralization therapies, both fluoride and non-fluoride based, aim to restore enamel, but limited comparative data exist on their effect...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/12/1/93 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589043829833728 |
|---|---|
| author | Ana Josefina Monjarás-Ávila Louis Hardan Carlos Enrique Cuevas-Suárez Norma Verónica Zavala Alonso Miguel Ángel Fernández-Barrera Carol Moussa Jamal Jabr Rim Bourgi Youssef Haikel |
| author_facet | Ana Josefina Monjarás-Ávila Louis Hardan Carlos Enrique Cuevas-Suárez Norma Verónica Zavala Alonso Miguel Ángel Fernández-Barrera Carol Moussa Jamal Jabr Rim Bourgi Youssef Haikel |
| author_sort | Ana Josefina Monjarás-Ávila |
| collection | DOAJ |
| description | Dental caries is a widespread issue impacting global oral health. White spot lesions, the earliest stage of caries, compromise enamel’s esthetics and integrity. Remineralization therapies, both fluoride and non-fluoride based, aim to restore enamel, but limited comparative data exist on their effects on lesion depth and microhardness. Thus, the aim of this systematic review was to evaluate the efficacy of remineralizing agents on lesion depth and microhardness of human teeth. The literature search included the following five databases: PubMed, Web of Science, Scielo, SCOPUS, and EMBASE from the period 2012 to October 2022. Studies evaluating lesion depth and microhardness in human teeth after the application of a remineralizing agent were considered for review. The meta-analysis was performed using RevMan 5.4 (The Cochrane Collaboration, Copenhagen, Denmark). A random effect model was used to pool estimate of effect and its 95% confidence intervals (CIs) for surface microhardness and depth lesion. Subgroup analyses were performed considering the presence of fluoride or not in the remineralization agent. Thirty-three studies were included in the qualitative review. Of these, twenty-six studies were included in the meta-analysis. The main risks of bias associated with the studies included a lack of blinding of the test operator and failure to obtain sample size. To conclude, fluorinated agents are more effective in remineralizing artificially induced white spot lesion than non-fluoride remineralizing agents. |
| format | Article |
| id | doaj-art-57023416835644e282772df136e21d46 |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-57023416835644e282772df136e21d462025-01-24T13:23:15ZengMDPI AGBioengineering2306-53542025-01-011219310.3390/bioengineering12010093Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot LesionsAna Josefina Monjarás-Ávila0Louis Hardan1Carlos Enrique Cuevas-Suárez2Norma Verónica Zavala Alonso3Miguel Ángel Fernández-Barrera4Carol Moussa5Jamal Jabr6Rim Bourgi7Youssef Haikel8Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, MexicoDepartment of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, MexicoFacultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, MexicoDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, MexicoFaculty of Dentistry, University of Tours, 37032 Tours, FrancePrivate Practice (Healthcare Center), L-1740 Hollerich, LuxembourgDepartment of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, FranceDental caries is a widespread issue impacting global oral health. White spot lesions, the earliest stage of caries, compromise enamel’s esthetics and integrity. Remineralization therapies, both fluoride and non-fluoride based, aim to restore enamel, but limited comparative data exist on their effects on lesion depth and microhardness. Thus, the aim of this systematic review was to evaluate the efficacy of remineralizing agents on lesion depth and microhardness of human teeth. The literature search included the following five databases: PubMed, Web of Science, Scielo, SCOPUS, and EMBASE from the period 2012 to October 2022. Studies evaluating lesion depth and microhardness in human teeth after the application of a remineralizing agent were considered for review. The meta-analysis was performed using RevMan 5.4 (The Cochrane Collaboration, Copenhagen, Denmark). A random effect model was used to pool estimate of effect and its 95% confidence intervals (CIs) for surface microhardness and depth lesion. Subgroup analyses were performed considering the presence of fluoride or not in the remineralization agent. Thirty-three studies were included in the qualitative review. Of these, twenty-six studies were included in the meta-analysis. The main risks of bias associated with the studies included a lack of blinding of the test operator and failure to obtain sample size. To conclude, fluorinated agents are more effective in remineralizing artificially induced white spot lesion than non-fluoride remineralizing agents.https://www.mdpi.com/2306-5354/12/1/93casein phosphopeptide–amorphous calcium phosphatehardnesslesion depthmeta-analysisremineralizationvarnish |
| spellingShingle | Ana Josefina Monjarás-Ávila Louis Hardan Carlos Enrique Cuevas-Suárez Norma Verónica Zavala Alonso Miguel Ángel Fernández-Barrera Carol Moussa Jamal Jabr Rim Bourgi Youssef Haikel Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions Bioengineering casein phosphopeptide–amorphous calcium phosphate hardness lesion depth meta-analysis remineralization varnish |
| title | Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions |
| title_full | Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions |
| title_fullStr | Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions |
| title_full_unstemmed | Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions |
| title_short | Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions |
| title_sort | systematic review and meta analysis of remineralizing agents outcomes on white spot lesions |
| topic | casein phosphopeptide–amorphous calcium phosphate hardness lesion depth meta-analysis remineralization varnish |
| url | https://www.mdpi.com/2306-5354/12/1/93 |
| work_keys_str_mv | AT anajosefinamonjarasavila systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT louishardan systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT carlosenriquecuevassuarez systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT normaveronicazavalaalonso systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT miguelangelfernandezbarrera systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT carolmoussa systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT jamaljabr systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT rimbourgi systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions AT youssefhaikel systematicreviewandmetaanalysisofremineralizingagentsoutcomesonwhitespotlesions |