Application of emerging technologies for gut microbiome research
Microbiome is associated with a wide range of diseases. The gut microbiome is also a dynamic reflection of health status, which can be modified, thus representing great potential to exploit the mechanisms that influence human physiology. Recent years have seen a dramatic rise in gut microbiome studi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2023-01-01
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| Series: | Singapore Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-432 |
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| _version_ | 1823861467841036288 |
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| author | Wit Thun Kwa Saishreyas Sundarajoo Kai Yee Toh Jonathan Lee |
| author_facet | Wit Thun Kwa Saishreyas Sundarajoo Kai Yee Toh Jonathan Lee |
| author_sort | Wit Thun Kwa |
| collection | DOAJ |
| description | Microbiome is associated with a wide range of diseases. The gut microbiome is also a dynamic reflection of health status, which can be modified, thus representing great potential to exploit the mechanisms that influence human physiology. Recent years have seen a dramatic rise in gut microbiome studies, which has been enabled by the rapidly evolving high-throughput sequencing methods (i.e. 16S rRNA sequencing and shotgun sequencing). As the emerging technologies for microbiome research continue to evolve (i.e. metatranscriptomics, metabolomics, culturomics, synthetic biology), microbiome research has moved beyond phylogenetic descriptions and towards mechanistic analyses. In this review, we highlight different approaches to study the microbiome, in particular, the current limitations and future promise of these techniques. This review aims to provide clinicians with a framework for studying the microbiome, as well as to accelerate the adoption of these techniques in clinical practice. |
| format | Article |
| id | doaj-art-56f6dc8e40a74b73a2671f19a5073967 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-56f6dc8e40a74b73a2671f19a50739672025-02-09T13:42:40ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-01-01641455210.4103/singaporemedj.SMJ-2021-432Application of emerging technologies for gut microbiome researchWit Thun KwaSaishreyas SundarajooKai Yee TohJonathan LeeMicrobiome is associated with a wide range of diseases. The gut microbiome is also a dynamic reflection of health status, which can be modified, thus representing great potential to exploit the mechanisms that influence human physiology. Recent years have seen a dramatic rise in gut microbiome studies, which has been enabled by the rapidly evolving high-throughput sequencing methods (i.e. 16S rRNA sequencing and shotgun sequencing). As the emerging technologies for microbiome research continue to evolve (i.e. metatranscriptomics, metabolomics, culturomics, synthetic biology), microbiome research has moved beyond phylogenetic descriptions and towards mechanistic analyses. In this review, we highlight different approaches to study the microbiome, in particular, the current limitations and future promise of these techniques. This review aims to provide clinicians with a framework for studying the microbiome, as well as to accelerate the adoption of these techniques in clinical practice.https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-432culturomicsfaecal microbiota transplantmetagenomicsmicrobiomemulti-omics |
| spellingShingle | Wit Thun Kwa Saishreyas Sundarajoo Kai Yee Toh Jonathan Lee Application of emerging technologies for gut microbiome research Singapore Medical Journal culturomics faecal microbiota transplant metagenomics microbiome multi-omics |
| title | Application of emerging technologies for gut microbiome research |
| title_full | Application of emerging technologies for gut microbiome research |
| title_fullStr | Application of emerging technologies for gut microbiome research |
| title_full_unstemmed | Application of emerging technologies for gut microbiome research |
| title_short | Application of emerging technologies for gut microbiome research |
| title_sort | application of emerging technologies for gut microbiome research |
| topic | culturomics faecal microbiota transplant metagenomics microbiome multi-omics |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-432 |
| work_keys_str_mv | AT witthunkwa applicationofemergingtechnologiesforgutmicrobiomeresearch AT saishreyassundarajoo applicationofemergingtechnologiesforgutmicrobiomeresearch AT kaiyeetoh applicationofemergingtechnologiesforgutmicrobiomeresearch AT jonathanlee applicationofemergingtechnologiesforgutmicrobiomeresearch |