Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats
Considerable experimental material has been accumulated on the influence of various abiotic environmental factors and various chemicals on the activity of some enzymes and multienzyme systems of mitochondria. Studying the effect of pesticides or defoliants on the functioning of the mitochondrial res...
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01022.pdf |
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| author | Tuychieva Dilfuza Alimova Rano Mirkhamidova Parida |
| author_facet | Tuychieva Dilfuza Alimova Rano Mirkhamidova Parida |
| author_sort | Tuychieva Dilfuza |
| collection | DOAJ |
| description | Considerable experimental material has been accumulated on the influence of various abiotic environmental factors and various chemicals on the activity of some enzymes and multienzyme systems of mitochondria. Studying the effect of pesticides or defoliants on the functioning of the mitochondrial respiratory chain is one of the most important tests used to decipher the primary mechanisms of intoxication in the body. A study of the state of the enzyme systems of liver mitochondrial membranes of pregnant rats and embryos shows that poisoning with defoliants - butylcaptax and dropp - reduces the activities of NAD.H oxidase, succinate oxidase and cytochrome c oxidase at all stages of pregnancy and embryonic development. The NAD.H-oxidase activity of mitochondria of pregnant rats and embryos was found to be most strongly inhibited by butylcaptax poisoning. Butylcaptax leads to a deeper inhibition of the rate of electron transfer in various fragments of the respiratory chain of liver mitochondria of pregnant rats and their embryos. The most profound inhibition is observed in the NAD.H oxidase pathway in case of butylcaptax poisoning on the 19th day of pregnancy |
| format | Article |
| id | doaj-art-56f312aca43a413ba85e90287d3e9cbb |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-56f312aca43a413ba85e90287d3e9cbb2025-08-20T02:19:40ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011490102210.1051/bioconf/202414901022bioconf_geneticresources2024_01022Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant ratsTuychieva Dilfuza0Alimova Rano1Mirkhamidova Parida2Andijan State UniversityTashkent State Agrarian UniversityTashkent State Pedagogical University named after NizomiConsiderable experimental material has been accumulated on the influence of various abiotic environmental factors and various chemicals on the activity of some enzymes and multienzyme systems of mitochondria. Studying the effect of pesticides or defoliants on the functioning of the mitochondrial respiratory chain is one of the most important tests used to decipher the primary mechanisms of intoxication in the body. A study of the state of the enzyme systems of liver mitochondrial membranes of pregnant rats and embryos shows that poisoning with defoliants - butylcaptax and dropp - reduces the activities of NAD.H oxidase, succinate oxidase and cytochrome c oxidase at all stages of pregnancy and embryonic development. The NAD.H-oxidase activity of mitochondria of pregnant rats and embryos was found to be most strongly inhibited by butylcaptax poisoning. Butylcaptax leads to a deeper inhibition of the rate of electron transfer in various fragments of the respiratory chain of liver mitochondria of pregnant rats and their embryos. The most profound inhibition is observed in the NAD.H oxidase pathway in case of butylcaptax poisoning on the 19th day of pregnancyhttps://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01022.pdf |
| spellingShingle | Tuychieva Dilfuza Alimova Rano Mirkhamidova Parida Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats BIO Web of Conferences |
| title | Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| title_full | Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| title_fullStr | Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| title_full_unstemmed | Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| title_short | Influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| title_sort | influence of poxidochemicals on enzyme systems of liver mitochondria membranes in pregnant rats |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01022.pdf |
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