Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed newborn infants and their mothers for nine months. The study found that antibody affinity (here measur...

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Bibliographic Details
Main Authors: Allan Lugaajju, Richard Idro, Stephen Kiwuwa, James G. Beeson, Damien R. Drew, Susanne E. Mortazavi, Sara Linse, Kristina E. M. Persson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
malaria
falciparum
affinity
antibodies
CSP
AMA1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562671/full
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