HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO)
Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. Objective: To determine the outcomes of patients presenting with dengue infection and describe the risk factors for mortality....
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| Format: | Article |
| Language: | English |
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Health Research Institute (HRI), National Institute of Health (NIH)
2025-02-01
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| Series: | Pakistan Journal of Medical Research |
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| Online Access: | https://www.pjmr.org.pk/index.php/pjmr/article/view/772 |
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| author | Aijaz Zeeshan Khan Omer Sabir Adnan Hussain Shahid Muhammad Bilal Basit Syeda Arzinda Fatima Shah Qamar Sajad |
| author_facet | Aijaz Zeeshan Khan Omer Sabir Adnan Hussain Shahid Muhammad Bilal Basit Syeda Arzinda Fatima Shah Qamar Sajad |
| author_sort | Aijaz Zeeshan Khan |
| collection | DOAJ |
| description |
Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes.
Objective: To determine the outcomes of patients presenting with dengue infection and describe the risk factors for mortality.
Study type, settings & duration: This prospective observational study was conducted in Intensive Care Units (ICUs) and Medical Wards, Department of Medicine, Fatima Memorial Hospital, Lahore from October 2021 to October 2023.
Methodology: A total of 215 patients presenting with characteristic symptoms and NS1 antigen and IgM. Anti Dengue antibodies positivity were included in current study. The hematological variables were recorded on day 1,3 and 5 after admission. Clinical and biochemical parameters were recorded on the day of admission. Clinical course of the patient was monitored and outcomes were recorded.
Results: Out of 215 patients, 11 (5.1%) expired. A significant association between female gender and the necessity for packed cell volume and fresh frozen plasma transfusion was observed (OR (95% CI: 10.26 (2.23 – 96.24), p =0.0005).The significant risk factors for mortality were: presence of ascites, pleural effusion, organ dysfunction, need for PCV, FFP and platelet megaunit transfusion. Higher hemoglobin on day 1 and 5 (P=0.05), higher WBCs on day 3 and 5 (p =0.0), platelets on day 5 (p =0.009), O2 saturations (p=0.0) and mean BP on presentation (p =0.008) (day 1) were significant predictors of death.
Conclusion: In patients with dengue infection, trend of hematological parameters should be be monitored closely on .........
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| format | Article |
| id | doaj-art-56e38b1e72c84ba8ad04bb98e4b4e901 |
| institution | Kabale University |
| issn | 0030-9842 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Health Research Institute (HRI), National Institute of Health (NIH) |
| record_format | Article |
| series | Pakistan Journal of Medical Research |
| spelling | doaj-art-56e38b1e72c84ba8ad04bb98e4b4e9012025-02-12T01:06:25ZengHealth Research Institute (HRI), National Institute of Health (NIH)Pakistan Journal of Medical Research0030-98422025-02-01634HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO)Aijaz Zeeshan Khan0Omer Sabir1Adnan Hussain Shahid2Muhammad Bilal Basit3Syeda Arzinda Fatima Shah4Qamar Sajad5Department of Medicine, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore.Department of Nephrology, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore.Department of Medicine, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore.Department of Nephrology, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore.Department of Medicine, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore.Department of Endocrinology, Fatima Memorial Hospital, Lahore. Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. Objective: To determine the outcomes of patients presenting with dengue infection and describe the risk factors for mortality. Study type, settings & duration: This prospective observational study was conducted in Intensive Care Units (ICUs) and Medical Wards, Department of Medicine, Fatima Memorial Hospital, Lahore from October 2021 to October 2023. Methodology: A total of 215 patients presenting with characteristic symptoms and NS1 antigen and IgM. Anti Dengue antibodies positivity were included in current study. The hematological variables were recorded on day 1,3 and 5 after admission. Clinical and biochemical parameters were recorded on the day of admission. Clinical course of the patient was monitored and outcomes were recorded. Results: Out of 215 patients, 11 (5.1%) expired. A significant association between female gender and the necessity for packed cell volume and fresh frozen plasma transfusion was observed (OR (95% CI: 10.26 (2.23 – 96.24), p =0.0005).The significant risk factors for mortality were: presence of ascites, pleural effusion, organ dysfunction, need for PCV, FFP and platelet megaunit transfusion. Higher hemoglobin on day 1 and 5 (P=0.05), higher WBCs on day 3 and 5 (p =0.0), platelets on day 5 (p =0.009), O2 saturations (p=0.0) and mean BP on presentation (p =0.008) (day 1) were significant predictors of death. Conclusion: In patients with dengue infection, trend of hematological parameters should be be monitored closely on ......... https://www.pjmr.org.pk/index.php/pjmr/article/view/772Dengue, Viral Hemorrhagic Fever, Vector borne diseases, Mosquitoe borne diseases |
| spellingShingle | Aijaz Zeeshan Khan Omer Sabir Adnan Hussain Shahid Muhammad Bilal Basit Syeda Arzinda Fatima Shah Qamar Sajad HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) Pakistan Journal of Medical Research Dengue, Viral Hemorrhagic Fever, Vector borne diseases, Mosquitoe borne diseases |
| title | HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) |
| title_full | HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) |
| title_fullStr | HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) |
| title_full_unstemmed | HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) |
| title_short | HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) |
| title_sort | heal dengue hospital based exploration analysis and learning about dengue outcomes heal d aldo |
| topic | Dengue, Viral Hemorrhagic Fever, Vector borne diseases, Mosquitoe borne diseases |
| url | https://www.pjmr.org.pk/index.php/pjmr/article/view/772 |
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