An Unusual Case of Giant Bullous Disease

Case Presentation: A 50-year-old African American woman presented to the lung transplant clinic for evaluation after experiencing gradually worsening dyspnea over the preceding 5 years. She had been diagnosed with COPD by another pulmonologist. Since her diagnosis 10 years before presentation, the p...

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Main Authors: Kenji Yoshino, MD, Jonathan Ioanitescu, MD, Haiying Zhang, MD, Tiana Endicott-Yazdani, MD, PhD, Susan K. Mathai, MD
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:CHEST Pulmonary
Online Access:http://www.sciencedirect.com/science/article/pii/S2949789224000874
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author Kenji Yoshino, MD
Jonathan Ioanitescu, MD
Haiying Zhang, MD
Tiana Endicott-Yazdani, MD, PhD
Susan K. Mathai, MD
author_facet Kenji Yoshino, MD
Jonathan Ioanitescu, MD
Haiying Zhang, MD
Tiana Endicott-Yazdani, MD, PhD
Susan K. Mathai, MD
author_sort Kenji Yoshino, MD
collection DOAJ
description Case Presentation: A 50-year-old African American woman presented to the lung transplant clinic for evaluation after experiencing gradually worsening dyspnea over the preceding 5 years. She had been diagnosed with COPD by another pulmonologist. Since her diagnosis 10 years before presentation, the patient had been on continuous supplemental oxygen therapy at 2 L/min. Her treatment regimen included a once daily combination inhaler (a corticosteroid and an ultra-long-acting ß-adrenoceptor agonist) along with an albuterol inhaler used as needed. The patient’s dyspnea limited her ability to walk half a block, and she often required a few minutes to recover after these efforts. Her symptoms were partially alleviated by use of her albuterol inhaler. In addition to dyspnea, the patient reported a nonproductive cough that was exacerbated by activity and relieved by rest. The patient’s medical history included OSA requiring positive airway pressure therapy and a hospitalization for respiratory distress due to a COVID-19 infection 12 months before presentation. She had a < 10-pack-year smoking history and childhood exposure to secondhand smoke. She had no known exposure to organic dusts or asbestos.
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spelling doaj-art-56df5abc33b947a2b4adab906c5d312e2025-08-20T02:30:23ZengElsevierCHEST Pulmonary2949-78922025-03-013110012110.1016/j.chpulm.2024.100121An Unusual Case of Giant Bullous DiseaseKenji Yoshino, MD0Jonathan Ioanitescu, MD1Haiying Zhang, MD2Tiana Endicott-Yazdani, MD, PhD3Susan K. Mathai, MD4Division of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, TX; CORRESPONDENCE TO: Kenji Yoshino, MDDivision of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, TXDepartment of Pathology, Baylor University Medical Center, Dallas, TXDivision of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, TX; Center for Advanced Heart &amp; Lung Disease, Baylor University Medical Center, Dallas, TX; Texas A&M University School of Medicine, Dallas, TXDivision of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, TX; Center for Advanced Heart &amp; Lung Disease, Baylor University Medical Center, Dallas, TX; Texas A&M University School of Medicine, Dallas, TXCase Presentation: A 50-year-old African American woman presented to the lung transplant clinic for evaluation after experiencing gradually worsening dyspnea over the preceding 5 years. She had been diagnosed with COPD by another pulmonologist. Since her diagnosis 10 years before presentation, the patient had been on continuous supplemental oxygen therapy at 2 L/min. Her treatment regimen included a once daily combination inhaler (a corticosteroid and an ultra-long-acting ß-adrenoceptor agonist) along with an albuterol inhaler used as needed. The patient’s dyspnea limited her ability to walk half a block, and she often required a few minutes to recover after these efforts. Her symptoms were partially alleviated by use of her albuterol inhaler. In addition to dyspnea, the patient reported a nonproductive cough that was exacerbated by activity and relieved by rest. The patient’s medical history included OSA requiring positive airway pressure therapy and a hospitalization for respiratory distress due to a COVID-19 infection 12 months before presentation. She had a < 10-pack-year smoking history and childhood exposure to secondhand smoke. She had no known exposure to organic dusts or asbestos.http://www.sciencedirect.com/science/article/pii/S2949789224000874
spellingShingle Kenji Yoshino, MD
Jonathan Ioanitescu, MD
Haiying Zhang, MD
Tiana Endicott-Yazdani, MD, PhD
Susan K. Mathai, MD
An Unusual Case of Giant Bullous Disease
CHEST Pulmonary
title An Unusual Case of Giant Bullous Disease
title_full An Unusual Case of Giant Bullous Disease
title_fullStr An Unusual Case of Giant Bullous Disease
title_full_unstemmed An Unusual Case of Giant Bullous Disease
title_short An Unusual Case of Giant Bullous Disease
title_sort unusual case of giant bullous disease
url http://www.sciencedirect.com/science/article/pii/S2949789224000874
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