NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 re...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/684238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546528199180288 |
|---|---|
| author | Tursonjan Tokay Timo Kirschstein Marco Rohde Volker Zschorlich Rüdiger Köhling |
| author_facet | Tursonjan Tokay Timo Kirschstein Marco Rohde Volker Zschorlich Rüdiger Köhling |
| author_sort | Tursonjan Tokay |
| collection | DOAJ |
| description | High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP. In contrast, the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation. HFMS-priming was diminished when applied in the presence of the metabotropic glutamate receptor antagonists (RS)-α-methylserine-O-phosphate (MSOP) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Moreover, when HFMS was delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 µM), CS-induced electrical LTP was again as high as under control conditions in slices without priming. These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved in this form of HFMS-induced metaplasticity. |
| format | Article |
| id | doaj-art-56dd7c4bf44a4514a332e2150f430ef0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-56dd7c4bf44a4514a332e2150f430ef02025-02-03T06:48:28ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/684238684238NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic StimulationTursonjan Tokay0Timo Kirschstein1Marco Rohde2Volker Zschorlich3Rüdiger Köhling4Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstraße 9, 18057 Rostock, GermanyOscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstraße 9, 18057 Rostock, GermanyOscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstraße 9, 18057 Rostock, GermanyInstitute of Sport Sciences, University of Rostock, Ulmenstraße 69, 18057 Rostock, GermanyOscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstraße 9, 18057 Rostock, GermanyHigh-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP. In contrast, the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation. HFMS-priming was diminished when applied in the presence of the metabotropic glutamate receptor antagonists (RS)-α-methylserine-O-phosphate (MSOP) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Moreover, when HFMS was delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 µM), CS-induced electrical LTP was again as high as under control conditions in slices without priming. These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved in this form of HFMS-induced metaplasticity.http://dx.doi.org/10.1155/2014/684238 |
| spellingShingle | Tursonjan Tokay Timo Kirschstein Marco Rohde Volker Zschorlich Rüdiger Köhling NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation Neural Plasticity |
| title | NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation |
| title_full | NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation |
| title_fullStr | NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation |
| title_full_unstemmed | NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation |
| title_short | NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation |
| title_sort | nmda receptor dependent metaplasticity by high frequency magnetic stimulation |
| url | http://dx.doi.org/10.1155/2014/684238 |
| work_keys_str_mv | AT tursonjantokay nmdareceptordependentmetaplasticitybyhighfrequencymagneticstimulation AT timokirschstein nmdareceptordependentmetaplasticitybyhighfrequencymagneticstimulation AT marcorohde nmdareceptordependentmetaplasticitybyhighfrequencymagneticstimulation AT volkerzschorlich nmdareceptordependentmetaplasticitybyhighfrequencymagneticstimulation AT rudigerkohling nmdareceptordependentmetaplasticitybyhighfrequencymagneticstimulation |