Diaphragmatic curvature analysis using dynamic digital radiography
Purpose: To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients. Methods: This retrospective study included healthy volunteers and COPD patients recruited from 2...
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Elsevier
2025-12-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047725000437 |
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| author | Takuya Hino Akinori Tsunomori Noriaki Wada Akinori Hata Taiki Fukuda Yusei Nakamura Yoshitake Yamada Tomoyuki Hida Mizuki Nishino Masako Ueyama Atsuko Kurosaki Takeshi Kubo Shoji Kudoh Kousei Ishigami Hiroto Hatabu |
| author_facet | Takuya Hino Akinori Tsunomori Noriaki Wada Akinori Hata Taiki Fukuda Yusei Nakamura Yoshitake Yamada Tomoyuki Hida Mizuki Nishino Masako Ueyama Atsuko Kurosaki Takeshi Kubo Shoji Kudoh Kousei Ishigami Hiroto Hatabu |
| author_sort | Takuya Hino |
| collection | DOAJ |
| description | Purpose: To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients. Methods: This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. AUD in full inspiration minus AUD in full expiration (ΔAUD) was also calculated. The diaphragmatic surface was demarcated manually on DDR image to calculate AUD. Three-group comparison of AUD and ΔAUD among normal, mild COPD, and severe COPD subjects was tested with one-way analysis of variance, followed by multiple comparison with Tukey-Kramer method. The diagnostic accuracy of COPD by ΔAUD was assessed using receiver-operating-characteristics (ROC) curve. Results: Sixty-eight participants (36 men, 29 COPD patients) were enrolled. AUD in full inspiration was larger in healthy volunteers than in COPD patients (right, p < 0.001; left, p = 0.02). ΔAUD were different in the three-group comparison (right, normal, 208.7 ± 184.6 mm2, mild COPD, −18.1 ± 117.5 mm2, severe COPD −97.5 ± 150.0 mm2, p < 0.001; left, normal, 254.9 ± 131.5 mm2, mild COPD, −12.5 ± 136.5 mm2, severe COPD, −100.7 ± 134.1 mm2, p < 0.001). ROC curve showed high diagnostic performance of COPD by unilateral ΔAUD (right, area-under curve 0.942; left, area-under-curve 0.965). Conclusion: The value of ΔAUD was smaller according to the severity of COPD. ΔAUD can be helpful in distinguishing healthy subjects from COPD patients. |
| format | Article |
| id | doaj-art-56d45e3be0cc45bd893360f007af107d |
| institution | Kabale University |
| issn | 2352-0477 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj-art-56d45e3be0cc45bd893360f007af107d2025-08-20T03:57:58ZengElsevierEuropean Journal of Radiology Open2352-04772025-12-011510067610.1016/j.ejro.2025.100676Diaphragmatic curvature analysis using dynamic digital radiographyTakuya Hino0Akinori Tsunomori1Noriaki Wada2Akinori Hata3Taiki Fukuda4Yusei Nakamura5Yoshitake Yamada6Tomoyuki Hida7Mizuki Nishino8Masako Ueyama9Atsuko Kurosaki10Takeshi Kubo11Shoji Kudoh12Kousei Ishigami13Hiroto Hatabu14Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, Japan; Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USA; Corresponding author at: Department of Clinical Radiology, Graduate School of Medical Science, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, Japan.Medical Imaging R&D Center, Healthcare Business Headquarters, KONICA MINOLTA, INC., 2970 Ishikawa-machi, Hachioji-shi, Tokyo, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, Japan; Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USADepartment of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, JapanCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USADepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, Japan; Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USADepartment of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, JapanCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USADepartment of Health Care, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, JapanDepartment of Diagnostic Radiology, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, JapanDepartment of Radiology, Tenri Hospital, 200 Mishimacho, Tenri, Nara, JapanJapan Anti-Tuberculosis Association, 1-3-12 Kanda-Misakicho, Chiyoda-ku, Tokyo, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, Fukuoka, JapanCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USAPurpose: To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients. Methods: This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. AUD in full inspiration minus AUD in full expiration (ΔAUD) was also calculated. The diaphragmatic surface was demarcated manually on DDR image to calculate AUD. Three-group comparison of AUD and ΔAUD among normal, mild COPD, and severe COPD subjects was tested with one-way analysis of variance, followed by multiple comparison with Tukey-Kramer method. The diagnostic accuracy of COPD by ΔAUD was assessed using receiver-operating-characteristics (ROC) curve. Results: Sixty-eight participants (36 men, 29 COPD patients) were enrolled. AUD in full inspiration was larger in healthy volunteers than in COPD patients (right, p < 0.001; left, p = 0.02). ΔAUD were different in the three-group comparison (right, normal, 208.7 ± 184.6 mm2, mild COPD, −18.1 ± 117.5 mm2, severe COPD −97.5 ± 150.0 mm2, p < 0.001; left, normal, 254.9 ± 131.5 mm2, mild COPD, −12.5 ± 136.5 mm2, severe COPD, −100.7 ± 134.1 mm2, p < 0.001). ROC curve showed high diagnostic performance of COPD by unilateral ΔAUD (right, area-under curve 0.942; left, area-under-curve 0.965). Conclusion: The value of ΔAUD was smaller according to the severity of COPD. ΔAUD can be helpful in distinguishing healthy subjects from COPD patients.http://www.sciencedirect.com/science/article/pii/S2352047725000437Chronic obstructive pulmonary diseaseRadiologyChest radiographDynamic digital radiography |
| spellingShingle | Takuya Hino Akinori Tsunomori Noriaki Wada Akinori Hata Taiki Fukuda Yusei Nakamura Yoshitake Yamada Tomoyuki Hida Mizuki Nishino Masako Ueyama Atsuko Kurosaki Takeshi Kubo Shoji Kudoh Kousei Ishigami Hiroto Hatabu Diaphragmatic curvature analysis using dynamic digital radiography European Journal of Radiology Open Chronic obstructive pulmonary disease Radiology Chest radiograph Dynamic digital radiography |
| title | Diaphragmatic curvature analysis using dynamic digital radiography |
| title_full | Diaphragmatic curvature analysis using dynamic digital radiography |
| title_fullStr | Diaphragmatic curvature analysis using dynamic digital radiography |
| title_full_unstemmed | Diaphragmatic curvature analysis using dynamic digital radiography |
| title_short | Diaphragmatic curvature analysis using dynamic digital radiography |
| title_sort | diaphragmatic curvature analysis using dynamic digital radiography |
| topic | Chronic obstructive pulmonary disease Radiology Chest radiograph Dynamic digital radiography |
| url | http://www.sciencedirect.com/science/article/pii/S2352047725000437 |
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