Animal models of human herpesvirus infection
Abstract Human herpesvirus, a specific group within the herpesvirus family, is responsible for a variety of human diseases. These viruses can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both hu...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Animal Models and Experimental Medicine |
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| Online Access: | https://doi.org/10.1002/ame2.12575 |
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| _version_ | 1849700497826512896 |
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| author | Ziqing Jia Dong Zhang Lin Zhu Jing Xue |
| author_facet | Ziqing Jia Dong Zhang Lin Zhu Jing Xue |
| author_sort | Ziqing Jia |
| collection | DOAJ |
| description | Abstract Human herpesvirus, a specific group within the herpesvirus family, is responsible for a variety of human diseases. These viruses can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing. Despite several vaccine candidates being in preclinical and clinical stages, no vaccines are current available to prevent lifelong infections caused by these human herpesviruses, except for varicella‐zoster virus (VZV) vaccine. However, the strict host tropism of herpesviruses and other limitations mean that no single animal model can fully replicate all key features of human herpesvirus‐associated diseases. This makes it challenging to evaluate vaccines and antivirals against human herpesvirus comprehensively. Herein, we summarize the current animal models used to study the human herpesviruses including α‐herpesviruses (herpes simplex virus type 1(HSV‐1), HSV‐2, VZV), β‐herpesviruses (human cytomegalovirus (HCMV), γ‐herpesviruses (Epstein–Barr virus (EBV)) and Kaposi's sarcoma herpesvirus (KSHV)). By providing concise information and detailed analysis of the potential, limitations and applications of various models, such as non‐human primates, mice, rabbits, guinea pigs, and tree shrews, this summary aims to help researchers efficiently select the most appropriate animal model, offering practical guidance for studying human herpesvirus. |
| format | Article |
| id | doaj-art-56d2ff164e3644ee9b653c39add00a1a |
| institution | DOAJ |
| issn | 2576-2095 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj-art-56d2ff164e3644ee9b653c39add00a1a2025-08-20T03:18:15ZengWileyAnimal Models and Experimental Medicine2576-20952025-04-018461562810.1002/ame2.12575Animal models of human herpesvirus infectionZiqing Jia0Dong Zhang1Lin Zhu2Jing Xue3NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract Human herpesvirus, a specific group within the herpesvirus family, is responsible for a variety of human diseases. These viruses can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing. Despite several vaccine candidates being in preclinical and clinical stages, no vaccines are current available to prevent lifelong infections caused by these human herpesviruses, except for varicella‐zoster virus (VZV) vaccine. However, the strict host tropism of herpesviruses and other limitations mean that no single animal model can fully replicate all key features of human herpesvirus‐associated diseases. This makes it challenging to evaluate vaccines and antivirals against human herpesvirus comprehensively. Herein, we summarize the current animal models used to study the human herpesviruses including α‐herpesviruses (herpes simplex virus type 1(HSV‐1), HSV‐2, VZV), β‐herpesviruses (human cytomegalovirus (HCMV), γ‐herpesviruses (Epstein–Barr virus (EBV)) and Kaposi's sarcoma herpesvirus (KSHV)). By providing concise information and detailed analysis of the potential, limitations and applications of various models, such as non‐human primates, mice, rabbits, guinea pigs, and tree shrews, this summary aims to help researchers efficiently select the most appropriate animal model, offering practical guidance for studying human herpesvirus.https://doi.org/10.1002/ame2.12575animal modelsEBVHSVhuman herpesvirusKSHVVZV |
| spellingShingle | Ziqing Jia Dong Zhang Lin Zhu Jing Xue Animal models of human herpesvirus infection Animal Models and Experimental Medicine animal models EBV HSV human herpesvirus KSHV VZV |
| title | Animal models of human herpesvirus infection |
| title_full | Animal models of human herpesvirus infection |
| title_fullStr | Animal models of human herpesvirus infection |
| title_full_unstemmed | Animal models of human herpesvirus infection |
| title_short | Animal models of human herpesvirus infection |
| title_sort | animal models of human herpesvirus infection |
| topic | animal models EBV HSV human herpesvirus KSHV VZV |
| url | https://doi.org/10.1002/ame2.12575 |
| work_keys_str_mv | AT ziqingjia animalmodelsofhumanherpesvirusinfection AT dongzhang animalmodelsofhumanherpesvirusinfection AT linzhu animalmodelsofhumanherpesvirusinfection AT jingxue animalmodelsofhumanherpesvirusinfection |