Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model

Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model

IntroductionHutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging, impacting multiple organ systems, including cardiovascular, musculoskeletal, and integumentary. Significant abnormalities in a transgenic mouse model (homozygous G608G mutation), spe...

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Main Authors: Indeevar Beeram, Maria Belen Cubria, Pramod Kamalapathy, Diana Yeritsyan, Amanda J. Dubose, Ahmad Hedayatzadeh Razavi, Nazanin Nafisi, Michael R. Erdos, Brian D. Snyder, Wayne A. Cabral, Francis S. Collins, Ara Nazarian
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Physiology
Subjects:
progeria
homozygous G608G progeria mouse model
maxillofacial abnormality
microCT (μCT)
morphology
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1481985/full
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