Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell
The incidence of prostate cancer (PCa) is increasing annually, making it the leading cause of tumor-related mortality in males. The available treatment options for metastatic PCa are limited. Vasculogenic mimicry (VM), an emerging phenomenon involving aggressive tumor cells, has a significant impact...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324002821 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138054198558720 |
|---|---|
| author | Bide Liu Xun Li Shuheng Wang Hongliang Jia Xiaoan Zhang Qiang Dong Jiuzhi Li |
| author_facet | Bide Liu Xun Li Shuheng Wang Hongliang Jia Xiaoan Zhang Qiang Dong Jiuzhi Li |
| author_sort | Bide Liu |
| collection | DOAJ |
| description | The incidence of prostate cancer (PCa) is increasing annually, making it the leading cause of tumor-related mortality in males. The available treatment options for metastatic PCa are limited. Vasculogenic mimicry (VM), an emerging phenomenon involving aggressive tumor cells, has a significant impact on patient survival. Misregulation of Wnt5a expression is commonly observed during cancer progression. However, there is a lack of comprehensive studies investigating the effects of Wnt5a on tumor VM formation. In this study, we demonstrate that alterations in wnt5a expression, either through gain or loss, have a significant influence on the formation of VM in tumor cells mediated by cell stemness and EMT progression. Further research has demonstrated that Wnt5a regulates the formation of VM through the PI3K/JNK signaling pathway. These experimental findings offer a novel avenue for the clinical management of prostate cancer. |
| format | Article |
| id | doaj-art-56cb46699ea84fb18ea4062a03482659 |
| institution | OA Journals |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-56cb46699ea84fb18ea4062a034826592025-08-20T02:30:39ZengElsevierTranslational Oncology1936-52332025-01-015110215510.1016/j.tranon.2024.102155Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cellBide Liu0Xun Li1Shuheng Wang2Hongliang Jia3Xiaoan Zhang4Qiang Dong5Jiuzhi Li6Department of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, ChinaDepartment of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Corresponding author at: Department of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.The incidence of prostate cancer (PCa) is increasing annually, making it the leading cause of tumor-related mortality in males. The available treatment options for metastatic PCa are limited. Vasculogenic mimicry (VM), an emerging phenomenon involving aggressive tumor cells, has a significant impact on patient survival. Misregulation of Wnt5a expression is commonly observed during cancer progression. However, there is a lack of comprehensive studies investigating the effects of Wnt5a on tumor VM formation. In this study, we demonstrate that alterations in wnt5a expression, either through gain or loss, have a significant influence on the formation of VM in tumor cells mediated by cell stemness and EMT progression. Further research has demonstrated that Wnt5a regulates the formation of VM through the PI3K/JNK signaling pathway. These experimental findings offer a novel avenue for the clinical management of prostate cancer.http://www.sciencedirect.com/science/article/pii/S1936523324002821Cell stemnessEMTJNK signalingProstate cancerVasculogenic mimicryWnt5a |
| spellingShingle | Bide Liu Xun Li Shuheng Wang Hongliang Jia Xiaoan Zhang Qiang Dong Jiuzhi Li Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell Translational Oncology Cell stemness EMT JNK signaling Prostate cancer Vasculogenic mimicry Wnt5a |
| title | Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell |
| title_full | Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell |
| title_fullStr | Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell |
| title_full_unstemmed | Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell |
| title_short | Wnt5a promotes VM formation by modulating the stemness and EMT progression of prostate cancer cell |
| title_sort | wnt5a promotes vm formation by modulating the stemness and emt progression of prostate cancer cell |
| topic | Cell stemness EMT JNK signaling Prostate cancer Vasculogenic mimicry Wnt5a |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324002821 |
| work_keys_str_mv | AT bideliu wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT xunli wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT shuhengwang wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT hongliangjia wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT xiaoanzhang wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT qiangdong wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell AT jiuzhili wnt5apromotesvmformationbymodulatingthestemnessandemtprogressionofprostatecancercell |