Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications
Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In i...
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000210 |
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| author | Jialian Wang Xingyu Tao Zhengyang Liu Yuan Yan Peifeng Cheng Bin Liu Huimin Du Bailin Niu |
| author_facet | Jialian Wang Xingyu Tao Zhengyang Liu Yuan Yan Peifeng Cheng Bin Liu Huimin Du Bailin Niu |
| author_sort | Jialian Wang |
| collection | DOAJ |
| description | Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In intensive care units (ICUs), the mortality rate of patients with SA-ALI remains high, mostly due to the absence of effective early diagnostic markers and suitable therapeutic strategies. Recent studies have demonstrated the importance of non-coding RNAs (ncRNAs) in the development and progression of SA-ALI. This review focuses on the critical roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating “cytokine storms”, oxidative stress, mitochondrial dysfunction, and programmed cell death in SA-ALI, and summarizes the current state and limitations of existing studies on lncRNAs and circRNAs in SA-ALI. By integrating advancements in high-throughput sequencing technologies, this review provides novel insights into the dual potential of ncRNAs as diagnostic biomarkers and therapeutic targets, offers new ideas for SA-ALI diagnosis and treatment research and highlights potential challenges in clinical translation. |
| format | Article |
| id | doaj-art-56c851f47a52425c9ed2bf3c3be43331 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-56c851f47a52425c9ed2bf3c3be433312025-02-08T04:59:46ZengElsevierPharmacological Research1096-11862025-02-01212107596Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applicationsJialian Wang0Xingyu Tao1Zhengyang Liu2Yuan Yan3Peifeng Cheng4Bin Liu5Huimin Du6Bailin Niu7Department of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, ChinaDepartment of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, ChinaDepartment of Nephrology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing University, Chongqing 400016, ChinaDepartment of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, ChinaDepartment of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, ChinaDepartment of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, ChinaDepartment of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Correspondence to: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, China.Department of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing 400016, China; Correspondence to: Department of Intensive Care Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Jiankang Road No.1, Yuzhong District, Chongqing 400016, China.Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In intensive care units (ICUs), the mortality rate of patients with SA-ALI remains high, mostly due to the absence of effective early diagnostic markers and suitable therapeutic strategies. Recent studies have demonstrated the importance of non-coding RNAs (ncRNAs) in the development and progression of SA-ALI. This review focuses on the critical roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating “cytokine storms”, oxidative stress, mitochondrial dysfunction, and programmed cell death in SA-ALI, and summarizes the current state and limitations of existing studies on lncRNAs and circRNAs in SA-ALI. By integrating advancements in high-throughput sequencing technologies, this review provides novel insights into the dual potential of ncRNAs as diagnostic biomarkers and therapeutic targets, offers new ideas for SA-ALI diagnosis and treatment research and highlights potential challenges in clinical translation.http://www.sciencedirect.com/science/article/pii/S1043661825000210SepsisAcute liver injuryNon-coding RNAMiRNALncRNACircRNA |
| spellingShingle | Jialian Wang Xingyu Tao Zhengyang Liu Yuan Yan Peifeng Cheng Bin Liu Huimin Du Bailin Niu Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications Pharmacological Research Sepsis Acute liver injury Non-coding RNA MiRNA LncRNA CircRNA |
| title | Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications |
| title_full | Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications |
| title_fullStr | Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications |
| title_full_unstemmed | Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications |
| title_short | Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications |
| title_sort | noncoding rnas in sepsis associated acute liver injury roles mechanisms and therapeutic applications |
| topic | Sepsis Acute liver injury Non-coding RNA MiRNA LncRNA CircRNA |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000210 |
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