Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications

Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications

Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In i...

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Bibliographic Details
Main Authors: Jialian Wang, Xingyu Tao, Zhengyang Liu, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Sepsis
Acute liver injury
Non-coding RNA
MiRNA
LncRNA
CircRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000210
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Summary:Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In intensive care units (ICUs), the mortality rate of patients with SA-ALI remains high, mostly due to the absence of effective early diagnostic markers and suitable therapeutic strategies. Recent studies have demonstrated the importance of non-coding RNAs (ncRNAs) in the development and progression of SA-ALI. This review focuses on the critical roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating “cytokine storms”, oxidative stress, mitochondrial dysfunction, and programmed cell death in SA-ALI, and summarizes the current state and limitations of existing studies on lncRNAs and circRNAs in SA-ALI. By integrating advancements in high-throughput sequencing technologies, this review provides novel insights into the dual potential of ncRNAs as diagnostic biomarkers and therapeutic targets, offers new ideas for SA-ALI diagnosis and treatment research and highlights potential challenges in clinical translation.
ISSN:1096-1186

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