KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma
Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/6403012 |
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| author | Yue-Feng Sun Hong-Li Wu Rui-Fang Shi Lin Chen Chao Meng |
| author_facet | Yue-Feng Sun Hong-Li Wu Rui-Fang Shi Lin Chen Chao Meng |
| author_sort | Yue-Feng Sun |
| collection | DOAJ |
| description | Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed. KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division. Additionally, KIF15 has been reported to participate in the growth of various types of tumors; however, the relation between KIF15 and HCC is unclear. Herein, our study investigated the possible role of KIF15 on the progression of HCC and found that KIF15 has high expression in tumor samples from HCC patients. KIF15 could play a critical role in the regulation of cell proliferation of HCC, which was proved by in vitro and in vivo assays. In conclusion, this study confirmed that KIF15 could be a novel therapeutic target for the treatment of HCC. |
| format | Article |
| id | doaj-art-56c6e1dbeba04ef68252ee05e62e5a77 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-56c6e1dbeba04ef68252ee05e62e5a772025-08-20T03:33:35ZengWileyAnalytical Cellular Pathology2210-71772210-71852020-01-01202010.1155/2020/64030126403012KIF15 Promotes Proliferation and Growth of Hepatocellular CarcinomaYue-Feng Sun0Hong-Li Wu1Rui-Fang Shi2Lin Chen3Chao Meng4Department of Clinical Laboratory, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, ChinaDepartment of Clinical Laboratory, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, ChinaDepartment of Pathology, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, ChinaDepartment of Clinical Laboratory, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, ChinaDepartment of Clinical Laboratory, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, ChinaLiver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed. KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division. Additionally, KIF15 has been reported to participate in the growth of various types of tumors; however, the relation between KIF15 and HCC is unclear. Herein, our study investigated the possible role of KIF15 on the progression of HCC and found that KIF15 has high expression in tumor samples from HCC patients. KIF15 could play a critical role in the regulation of cell proliferation of HCC, which was proved by in vitro and in vivo assays. In conclusion, this study confirmed that KIF15 could be a novel therapeutic target for the treatment of HCC.http://dx.doi.org/10.1155/2020/6403012 |
| spellingShingle | Yue-Feng Sun Hong-Li Wu Rui-Fang Shi Lin Chen Chao Meng KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma Analytical Cellular Pathology |
| title | KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma |
| title_full | KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma |
| title_fullStr | KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma |
| title_full_unstemmed | KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma |
| title_short | KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma |
| title_sort | kif15 promotes proliferation and growth of hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2020/6403012 |
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