Modern basal insulins: an ongoing story or the start of a new era?
Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin,...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2015-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7693 |
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| author | Ivan Ivanovich Dedov |
| author_facet | Ivan Ivanovich Dedov |
| author_sort | Ivan Ivanovich Dedov |
| collection | DOAJ |
| description | Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin, currently available basal insulin products do not optimally mimic the endogenous profile of insulin. Although basal insulin analogues have some advantages over neutral protamine Hagedorn insulin in diabetes treatment, hypoglycaemia remains the main problem in the achievement of optimal glycaemic control in most patients with diabetes. These unmet clinical needs have stimulated the development of new basal insulin analogues with improved pharmacological profiles. This article reviews the specific characteristics of new long-acting insulin analogues to try and understand their benefits and limitations in the improvement of diabetes management and their possibilities in physiologic and safe insulin replacement. |
| format | Article |
| id | doaj-art-56c4eb10926d4375bf48510fb0af4b63 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-56c4eb10926d4375bf48510fb0af4b632025-08-20T01:57:09ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-12-0118451110.14341/DM76937264Modern basal insulins: an ongoing story or the start of a new era?Ivan Ivanovich Dedov0Endocrinology Research CentreBasal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin, currently available basal insulin products do not optimally mimic the endogenous profile of insulin. Although basal insulin analogues have some advantages over neutral protamine Hagedorn insulin in diabetes treatment, hypoglycaemia remains the main problem in the achievement of optimal glycaemic control in most patients with diabetes. These unmet clinical needs have stimulated the development of new basal insulin analogues with improved pharmacological profiles. This article reviews the specific characteristics of new long-acting insulin analogues to try and understand their benefits and limitations in the improvement of diabetes management and their possibilities in physiologic and safe insulin replacement.https://www.dia-endojournals.ru/jour/article/view/7693diabetes mellitusinsulin therapybasal insulin analogues evolutiondegludec |
| spellingShingle | Ivan Ivanovich Dedov Modern basal insulins: an ongoing story or the start of a new era? Сахарный диабет diabetes mellitus insulin therapy basal insulin analogues evolution degludec |
| title | Modern basal insulins: an ongoing story or the start of a new era? |
| title_full | Modern basal insulins: an ongoing story or the start of a new era? |
| title_fullStr | Modern basal insulins: an ongoing story or the start of a new era? |
| title_full_unstemmed | Modern basal insulins: an ongoing story or the start of a new era? |
| title_short | Modern basal insulins: an ongoing story or the start of a new era? |
| title_sort | modern basal insulins an ongoing story or the start of a new era |
| topic | diabetes mellitus insulin therapy basal insulin analogues evolution degludec |
| url | https://www.dia-endojournals.ru/jour/article/view/7693 |
| work_keys_str_mv | AT ivanivanovichdedov modernbasalinsulinsanongoingstoryorthestartofanewera |