PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting
Genetic research has elucidated molecular mechanisms of heart failure (HF). Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF. The aim of study was to find the correlation between PPARγ expression during development of HF in patients and coronary artery disea...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2014/242790 |
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| author | Izabela Wojtkowska Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Zbigniew Juraszyński Milosz Marona Lidia Greszata Anna Skrobisz Karol Kaminski Robert Sawicki Janina Stępińska |
| author_facet | Izabela Wojtkowska Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Zbigniew Juraszyński Milosz Marona Lidia Greszata Anna Skrobisz Karol Kaminski Robert Sawicki Janina Stępińska |
| author_sort | Izabela Wojtkowska |
| collection | DOAJ |
| description | Genetic research has elucidated molecular mechanisms of heart failure (HF). Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF. The aim of study was to find the correlation between PPARγ expression during development of HF in patients and coronary artery disease (CAD) after coronary artery bypass-grafting (CABG). Methods and Results. We followed up 157 patients (mean age 63) with CAD without clinical, laboratory, or echo parameters of HF who underwent CABG. Clinical and laboratory status were assessed before CABG and at 1, 12, and 24 months. During CABG slices of aorta (Ao) and LV were collected for genetic research. HF was defined as LVEF <40% or NT-proBNP >400 pg/mL or 6MWT <400 m. Patients were divided into 2 groups: with and without HF. PPARγ expression in Ao and LV was not increased in both groups at 2-year follow-up. Sensitivity of PPARγ expression in Ao above 1.1075 in detection of HF was 20.5% (AUC 0.531, 95% CI 0.442–0.619). Positive predictive value (Ppv) was 85.7%. Sensitivity and specificity of PPARγ expression in the LV in detection of HF were 58% and 92.9%, respectively (AUC 0.540, 95% CI 0.452–0.626). Ppv was 73.2%. Conclusion. PPARγ expression in Ao and LV was comparable and should not be used as predictive factor for development of HF in patients with CAD after CABG. |
| format | Article |
| id | doaj-art-56c15669c3644854b2f3ff5b918fee3e |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-56c15669c3644854b2f3ff5b918fee3e2025-02-03T06:06:25ZengWileyPPAR Research1687-47571687-47652014-01-01201410.1155/2014/242790242790PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-GraftingIzabela Wojtkowska0Andrzej Tysarowski1Katarzyna Seliga2Janusz A. Siedlecki3Zbigniew Juraszyński4Milosz Marona5Lidia Greszata6Anna Skrobisz7Karol Kaminski8Robert Sawicki9Janina Stępińska10Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandDepartment of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, PolandDepartment of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, PolandDepartment of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, PolandDepartment of Cardiosurgery and Transplantology, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandIntensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandIntensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandIntensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandDepartment of Cardiology, Medical University of Bialystok, 27a Sklodowska Street, 15-276 Bialystok, PolandDepartment of Cardiology, Medical University of Bialystok, 27a Sklodowska Street, 15-276 Bialystok, PolandIntensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, PolandGenetic research has elucidated molecular mechanisms of heart failure (HF). Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF. The aim of study was to find the correlation between PPARγ expression during development of HF in patients and coronary artery disease (CAD) after coronary artery bypass-grafting (CABG). Methods and Results. We followed up 157 patients (mean age 63) with CAD without clinical, laboratory, or echo parameters of HF who underwent CABG. Clinical and laboratory status were assessed before CABG and at 1, 12, and 24 months. During CABG slices of aorta (Ao) and LV were collected for genetic research. HF was defined as LVEF <40% or NT-proBNP >400 pg/mL or 6MWT <400 m. Patients were divided into 2 groups: with and without HF. PPARγ expression in Ao and LV was not increased in both groups at 2-year follow-up. Sensitivity of PPARγ expression in Ao above 1.1075 in detection of HF was 20.5% (AUC 0.531, 95% CI 0.442–0.619). Positive predictive value (Ppv) was 85.7%. Sensitivity and specificity of PPARγ expression in the LV in detection of HF were 58% and 92.9%, respectively (AUC 0.540, 95% CI 0.452–0.626). Ppv was 73.2%. Conclusion. PPARγ expression in Ao and LV was comparable and should not be used as predictive factor for development of HF in patients with CAD after CABG.http://dx.doi.org/10.1155/2014/242790 |
| spellingShingle | Izabela Wojtkowska Andrzej Tysarowski Katarzyna Seliga Janusz A. Siedlecki Zbigniew Juraszyński Milosz Marona Lidia Greszata Anna Skrobisz Karol Kaminski Robert Sawicki Janina Stępińska PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting PPAR Research |
| title | PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting |
| title_full | PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting |
| title_fullStr | PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting |
| title_full_unstemmed | PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting |
| title_short | PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting |
| title_sort | ppar gamma expression levels during development of heart failure in patients with coronary artery disease after coronary artery bypass grafting |
| url | http://dx.doi.org/10.1155/2014/242790 |
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