Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia

Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia

Abstract Global ischemic brain injury occurs after cardiac arrest or prolonged hypotensive episodes following surgery or trauma. It causes significant neurological deficits even after successful re-establishment of blood flow. It is the primary cause of death in 68% of inpatient and 23% of out-of-ho...

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Main Authors: Natasha Ting Lee, Ioanna Savvidou, Carly Selan, David K. Wright, Robert Brkljaca, Joanne S.J. Chia, Ilaria Calvello, Daphne D.D. Craenmehr, Pia Larsson, Volga Tarlac, Amy Vuong, Irena Carmichael, Xiaowei Wang, Karlheinz Peter, Simon C. Robson, Harshal H. Nandurkar, Maithili Sashindranath
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Ischaemia
Dual carotid artery ligation
Global hypoxia
CD39
VCAM-1
Online Access:https://doi.org/10.1186/s12974-025-03394-7
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