Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer
Objective. To explore the correlations of cancer-related fatigue (CRF) with clinicopathological features and quality of life in gastric cancer. Methods. Using a convenient sampling method, 230 patients with gastric cancer admitted to our hospital from March 2020 to July 2022 were collected. They wer...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/4850745 |
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| author | Dong Liu A-Dong Xia Yue-Long Xing Kai Zhang Dan Chen |
| author_facet | Dong Liu A-Dong Xia Yue-Long Xing Kai Zhang Dan Chen |
| author_sort | Dong Liu |
| collection | DOAJ |
| description | Objective. To explore the correlations of cancer-related fatigue (CRF) with clinicopathological features and quality of life in gastric cancer. Methods. Using a convenient sampling method, 230 patients with gastric cancer admitted to our hospital from March 2020 to July 2022 were collected. They were divided into the fatigue group (n=152) and the nonfatigue group (n=78) according to the presence/absence of CRF. Relevant data were collected and compared. Results. Statistically significant differences were found between the two groups in age ratio (χ2=41.671, P<0.001), T stage ratio (χ2=9.973, P=0.019), N stage ratio (P<0.001), PS score (P<0.001), and the degree of gastric cancer thickening (14.21±3.32 vs. 12.12±3.81 mm, t=4.572, P<0.001). Patients with gastric cancer had the lowest CRF Brief Fatigue Inventory (BFI) score for general activities (2.26±0.37) and high scores for work activities (6.23±0.24) and enjoyment of life (7.11±1.34). Pearson’s correlation analysis revealed a positive correlation between patient emotions and the CRF BFI score (r=0.443, P=0.001). Patients with mild, moderate, and severe CRF showed statistically significant differences in physical functioning (83.34±21.12 vs. 65.23±21.14 vs. 32.25±17.29, F=15.382, P<0.001), role emotional (72.53±21.21 vs. 67.33±27.56 vs. 54.37±26.45, F=14.483, P<0.001), fatigue (49.12±18.44 vs. 54.61±26.64 vs. 67.51±14.27, F=13.581, P<0.001), bodily pain (56.56±25.12 vs. 76.43±21.71 vs. 80.32±12.39, F=14.582, P<0.001), appetite reduction (57.45±25.47 vs. 69.51±16.21 vs. 76.23±27.58, F=14.592, P<0.001), and overall health status and quality of life (67.21±19.45 vs. 53.43±22.32 vs. 43.43±12.52, F=16.494, P<0.001). After chemotherapy, the average CRF BFI scores of the partial remission (PR), disease stability (SD), and disease progression (PD) groups all reduced than those before chemotherapy (all P<0.05). At 3 months of follow-up, a comparison of the average CRF BFI scores with those before chemotherapy revealed a decrease in the SD and PR groups and an increase in the PD group. Conclusion. In conclusion, CRF is correlated with age, T stage, and N stage in gastric cancer. The later the T and N stages, the more significant the effect on fatigue. Moreover, CRF can also affect the quality of life in gastric cancer, and the severer the CRF, the poorer the quality of life. |
| format | Article |
| id | doaj-art-56bb90284dbc4e6a8bf26eac74242c0a |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-56bb90284dbc4e6a8bf26eac74242c0a2025-02-03T11:53:47ZengWileyGastroenterology Research and Practice1687-630X2024-01-01202410.1155/2024/4850745Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric CancerDong Liu0A-Dong Xia1Yue-Long Xing2Kai Zhang3Dan Chen4Department of Hepatobiliary and Pancreatic GastroenterologyDepartment of Hepatobiliary and Pancreatic GastroenterologyDepartment of Hepatobiliary and Pancreatic GastroenterologyDepartment of Hepatobiliary and Pancreatic GastroenterologyDepartment of Hepatobiliary and Pancreatic GastroenterologyObjective. To explore the correlations of cancer-related fatigue (CRF) with clinicopathological features and quality of life in gastric cancer. Methods. Using a convenient sampling method, 230 patients with gastric cancer admitted to our hospital from March 2020 to July 2022 were collected. They were divided into the fatigue group (n=152) and the nonfatigue group (n=78) according to the presence/absence of CRF. Relevant data were collected and compared. Results. Statistically significant differences were found between the two groups in age ratio (χ2=41.671, P<0.001), T stage ratio (χ2=9.973, P=0.019), N stage ratio (P<0.001), PS score (P<0.001), and the degree of gastric cancer thickening (14.21±3.32 vs. 12.12±3.81 mm, t=4.572, P<0.001). Patients with gastric cancer had the lowest CRF Brief Fatigue Inventory (BFI) score for general activities (2.26±0.37) and high scores for work activities (6.23±0.24) and enjoyment of life (7.11±1.34). Pearson’s correlation analysis revealed a positive correlation between patient emotions and the CRF BFI score (r=0.443, P=0.001). Patients with mild, moderate, and severe CRF showed statistically significant differences in physical functioning (83.34±21.12 vs. 65.23±21.14 vs. 32.25±17.29, F=15.382, P<0.001), role emotional (72.53±21.21 vs. 67.33±27.56 vs. 54.37±26.45, F=14.483, P<0.001), fatigue (49.12±18.44 vs. 54.61±26.64 vs. 67.51±14.27, F=13.581, P<0.001), bodily pain (56.56±25.12 vs. 76.43±21.71 vs. 80.32±12.39, F=14.582, P<0.001), appetite reduction (57.45±25.47 vs. 69.51±16.21 vs. 76.23±27.58, F=14.592, P<0.001), and overall health status and quality of life (67.21±19.45 vs. 53.43±22.32 vs. 43.43±12.52, F=16.494, P<0.001). After chemotherapy, the average CRF BFI scores of the partial remission (PR), disease stability (SD), and disease progression (PD) groups all reduced than those before chemotherapy (all P<0.05). At 3 months of follow-up, a comparison of the average CRF BFI scores with those before chemotherapy revealed a decrease in the SD and PR groups and an increase in the PD group. Conclusion. In conclusion, CRF is correlated with age, T stage, and N stage in gastric cancer. The later the T and N stages, the more significant the effect on fatigue. Moreover, CRF can also affect the quality of life in gastric cancer, and the severer the CRF, the poorer the quality of life.http://dx.doi.org/10.1155/2024/4850745 |
| spellingShingle | Dong Liu A-Dong Xia Yue-Long Xing Kai Zhang Dan Chen Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer Gastroenterology Research and Practice |
| title | Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer |
| title_full | Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer |
| title_fullStr | Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer |
| title_full_unstemmed | Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer |
| title_short | Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer |
| title_sort | correlations of cancer related fatigue with clinicopathological features and quality of life in gastric cancer |
| url | http://dx.doi.org/10.1155/2024/4850745 |
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