Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis
Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/527989 |
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| _version_ | 1832552011141218304 |
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| author | Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer |
| author_facet | Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer |
| author_sort | Henning Neubauer |
| collection | DOAJ |
| description | Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury. |
| format | Article |
| id | doaj-art-56aff6d5650b40a58a964ac0b47cc64b |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-56aff6d5650b40a58a964ac0b47cc64b2025-02-03T05:59:44ZengWileyCase Reports in Pediatrics2090-68032090-68112012-01-01201210.1155/2012/527989527989Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic FibrosisHenning Neubauer0Clemens Wirth1Katharina Ruf2Helge Hebestreit3Meinrad Beer4Department of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatrics, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatrics, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyDepartment of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, GermanyCystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury.http://dx.doi.org/10.1155/2012/527989 |
| spellingShingle | Henning Neubauer Clemens Wirth Katharina Ruf Helge Hebestreit Meinrad Beer Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis Case Reports in Pediatrics |
| title | Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis |
| title_full | Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis |
| title_fullStr | Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis |
| title_full_unstemmed | Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis |
| title_short | Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis |
| title_sort | acute muscle trauma due to overexercise in an otherwise healthy patient with cystic fibrosis |
| url | http://dx.doi.org/10.1155/2012/527989 |
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