Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection

This study investigated the role of the nuclear factor of activated T cells c3 (NFATc3) in vascular smooth muscle cells (VSMCs) during aortic aneurysm and dissection (AAD) progression and the underlying molecular mechanisms. Cytoplasmic and nuclear NFATc3 levels were elevated in human and mouse AAD....

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Bibliographic Details
Main Authors:	Xiu Liu, Li Zhao, Deshen Liu, Lingna Zhao, Yonghua Tuo, Qinbao Peng, Fangze Huang, Zhengkun Song, Chuanjie Niu, Xiaoxia He, Yu Xu, Jun Wan, Peng Zhu, Zhengyang Jian, Jiawei Guo, Yingying Liu, Jun Lu, Sijia Liang, Shaoyi Zheng
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Aortic aneurysm and dissection NFATc3 eEF2 Translational elongation Extracellular matrix degradation MMP2
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383525003223
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Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection

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