Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease
Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1384658 |
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| _version_ | 1850223358915903488 |
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| author | Kai Zhu Jun Li Yulin Wang Hao Lai Chunsheng Wang |
| author_facet | Kai Zhu Jun Li Yulin Wang Hao Lai Chunsheng Wang |
| author_sort | Kai Zhu |
| collection | DOAJ |
| description | Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be tracked in vivo under multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed. |
| format | Article |
| id | doaj-art-56a8e51512be4dbc86bb9edb084e3380 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-56a8e51512be4dbc86bb9edb084e33802025-08-20T02:05:59ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/13846581384658Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart DiseaseKai Zhu0Jun Li1Yulin Wang2Hao Lai3Chunsheng Wang4Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaStem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be tracked in vivo under multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed.http://dx.doi.org/10.1155/2016/1384658 |
| spellingShingle | Kai Zhu Jun Li Yulin Wang Hao Lai Chunsheng Wang Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease Stem Cells International |
| title | Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease |
| title_full | Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease |
| title_fullStr | Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease |
| title_full_unstemmed | Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease |
| title_short | Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease |
| title_sort | nanoparticles assisted stem cell therapy for ischemic heart disease |
| url | http://dx.doi.org/10.1155/2016/1384658 |
| work_keys_str_mv | AT kaizhu nanoparticlesassistedstemcelltherapyforischemicheartdisease AT junli nanoparticlesassistedstemcelltherapyforischemicheartdisease AT yulinwang nanoparticlesassistedstemcelltherapyforischemicheartdisease AT haolai nanoparticlesassistedstemcelltherapyforischemicheartdisease AT chunshengwang nanoparticlesassistedstemcelltherapyforischemicheartdisease |