Tissue chips as headway model and incitement technology
Tissue on a chip or organ-on-chip (OOC) is a technology that's dignified to form a transformation in drug discovery through the use of advanced platforms. These are 3D in-vitro cell culture models that mimic micro-environment of human organs or tissues on artificial microstructures built on a p...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-03-01
|
| Series: | Synthetic and Systems Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X24001182 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849715529197027328 |
|---|---|
| author | Prerna Suchitan Modi Abhishek Singh Awyang Chaturvedi Shailly Agarwal Raghav Dutta Ranu Nayak Alok Kumar Singh |
| author_facet | Prerna Suchitan Modi Abhishek Singh Awyang Chaturvedi Shailly Agarwal Raghav Dutta Ranu Nayak Alok Kumar Singh |
| author_sort | Prerna Suchitan Modi |
| collection | DOAJ |
| description | Tissue on a chip or organ-on-chip (OOC) is a technology that's dignified to form a transformation in drug discovery through the use of advanced platforms. These are 3D in-vitro cell culture models that mimic micro-environment of human organs or tissues on artificial microstructures built on a portable microfluidic chip without involving sacrificial humans or animals.This review article aims to offer readers a thorough and insightful understanding of technology. It begins with an in-depth understanding of chip design and instrumentation, underlining its pivotal role and the imperative need for its development in the modern scientific landscape. The review article explores into the myriad applications of OOC technology, showcasing its transformative impact on fields such as radiobiology, drug discovery and screening, and its pioneering use in space research. In addition to highlighting these diverse applications, the article provides a critical analysis of the current challenges that OOC technology faces. It examines both the biological and technical limitations that hinder its progress and efficacy and discusses the potential advancements and innovations that could drive the OOC technology forward. Through this comprehensive review, readers will gain a deep appreciation of the significance, capabilities, and evolving landscape of OOC technology. |
| format | Article |
| id | doaj-art-56a7f8d0100b4922b74bfc56e0c7e965 |
| institution | DOAJ |
| issn | 2405-805X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj-art-56a7f8d0100b4922b74bfc56e0c7e9652025-08-20T03:13:21ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2025-03-011018610110.1016/j.synbio.2024.08.007Tissue chips as headway model and incitement technologyPrerna Suchitan Modi0Abhishek Singh1Awyang Chaturvedi2Shailly Agarwal3Raghav Dutta4Ranu Nayak5Alok Kumar Singh6Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, IndiaAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, IndiaAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, IndiaAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, IndiaAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, IndiaAmity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India; Corresponding author.Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India; Corresponding author.Tissue on a chip or organ-on-chip (OOC) is a technology that's dignified to form a transformation in drug discovery through the use of advanced platforms. These are 3D in-vitro cell culture models that mimic micro-environment of human organs or tissues on artificial microstructures built on a portable microfluidic chip without involving sacrificial humans or animals.This review article aims to offer readers a thorough and insightful understanding of technology. It begins with an in-depth understanding of chip design and instrumentation, underlining its pivotal role and the imperative need for its development in the modern scientific landscape. The review article explores into the myriad applications of OOC technology, showcasing its transformative impact on fields such as radiobiology, drug discovery and screening, and its pioneering use in space research. In addition to highlighting these diverse applications, the article provides a critical analysis of the current challenges that OOC technology faces. It examines both the biological and technical limitations that hinder its progress and efficacy and discusses the potential advancements and innovations that could drive the OOC technology forward. Through this comprehensive review, readers will gain a deep appreciation of the significance, capabilities, and evolving landscape of OOC technology.http://www.sciencedirect.com/science/article/pii/S2405805X240011823D cell cultureMicrofluidic deviceOrgan-on-chip2D cell culture3-Dimensional spheroid |
| spellingShingle | Prerna Suchitan Modi Abhishek Singh Awyang Chaturvedi Shailly Agarwal Raghav Dutta Ranu Nayak Alok Kumar Singh Tissue chips as headway model and incitement technology Synthetic and Systems Biotechnology 3D cell culture Microfluidic device Organ-on-chip 2D cell culture 3-Dimensional spheroid |
| title | Tissue chips as headway model and incitement technology |
| title_full | Tissue chips as headway model and incitement technology |
| title_fullStr | Tissue chips as headway model and incitement technology |
| title_full_unstemmed | Tissue chips as headway model and incitement technology |
| title_short | Tissue chips as headway model and incitement technology |
| title_sort | tissue chips as headway model and incitement technology |
| topic | 3D cell culture Microfluidic device Organ-on-chip 2D cell culture 3-Dimensional spheroid |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X24001182 |
| work_keys_str_mv | AT prernasuchitanmodi tissuechipsasheadwaymodelandincitementtechnology AT abhisheksingh tissuechipsasheadwaymodelandincitementtechnology AT awyangchaturvedi tissuechipsasheadwaymodelandincitementtechnology AT shaillyagarwal tissuechipsasheadwaymodelandincitementtechnology AT raghavdutta tissuechipsasheadwaymodelandincitementtechnology AT ranunayak tissuechipsasheadwaymodelandincitementtechnology AT alokkumarsingh tissuechipsasheadwaymodelandincitementtechnology |