Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol.

Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol.

<h4>Background</h4>Streptococcus pneumoniae (pneumococcus) and respiratory syncytial virus (RSV) are major causes of respiratory infections globally. Viral and bacterial co-infections are commonly observed in respiratory infections and there is evidence that these pathogens interact syne...

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Main Authors: Sanjita Brito-Mutunayagam, David O Hamilton, Elena Mitsi, Carla Solórzano, Grace Li, Bruno Rocha De Macedo, Filora Elterish, Xinxue Liu, Kiarash Tanha, Rachel White, Angela Hyder-Wright, Bhumika Patel, Britta C Urban, Conor Whelan, Hanane Trari Belhadef, Hannah Robinson, Emma Plested, Amber Thompson, Maria Lahuerta, Isis Kanevsky, Kena Swanson, Negar Aliabadi, Julie Catusse, Christian Theilacker, Bradford D Gessner, Natalie I Mazur, Christopher Chiu, Andrea M Collins, Ben Morton, Maheshi N Ramasamy, Daniela M Ferreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325149
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