Associations between indicators of lipid and glucose metabolism and hypothyroidism
Abstract Background Hypothyroidism, a prevalent thyroid hormone abnormality identified by biochemical indicators, is prone to serious consequences because of its insidious clinical manifestations and easy underdiagnosis. This research aimed to elucidate the relationships between indicators of lipid...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02457-1 |
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| author | Xinyi Huang Hengzheng Cheng Shuting Wang Laifu Deng Jiaxiu Li An Qin Chunqiang Chu Xiao Liu |
| author_facet | Xinyi Huang Hengzheng Cheng Shuting Wang Laifu Deng Jiaxiu Li An Qin Chunqiang Chu Xiao Liu |
| author_sort | Xinyi Huang |
| collection | DOAJ |
| description | Abstract Background Hypothyroidism, a prevalent thyroid hormone abnormality identified by biochemical indicators, is prone to serious consequences because of its insidious clinical manifestations and easy underdiagnosis. This research aimed to elucidate the relationships between indicators of lipid and glucose metabolism and hypothyroidism and to assess the value of metabolic indicators for hypothyroidism. Methods Prevalence surveys were conducted utilizing information from 3254 NHANES individuals who passed screening between 2007 and 2012. Comparisons of baseline characteristics, assessment of logistic regression and subgroup analyses, visualization of restricted cubic splines curves, and validation of causal mediation analyses were performed to obtain a comprehensive view of the relationships between indicators of lipid and glucose metabolism and hypothyroidism. Results Lipid and glucose metabolism indicators, especially the unconventional parameters triglyceride‒glucose index (TyG) and remnant cholesterol (RC) and the conventional parameter triglyceride (TG), exhibited robust positive relationships with hypothyroidism and served as crucial mediators in the pathways by which hypothyroidism affects health outcomes. Indicators were varying suggestive for hypothyroidism in distinct populations, with TyG being relatively more valuable. Conclusions Indicators of lipid and glucose metabolism (TyG, TG, and RC) were intimately associated with hypothyroidism, with potential applications in the assessment and management of hypothyroidism. |
| format | Article |
| id | doaj-art-56a12829cc1e49609d89812e6b645e9a |
| institution | OA Journals |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-56a12829cc1e49609d89812e6b645e9a2025-08-20T02:15:11ZengBMCLipids in Health and Disease1476-511X2025-02-0124111210.1186/s12944-025-02457-1Associations between indicators of lipid and glucose metabolism and hypothyroidismXinyi Huang0Hengzheng Cheng1Shuting Wang2Laifu Deng3Jiaxiu Li4An Qin5Chunqiang Chu6Xiao Liu7Department of General Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of General Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of General Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of General Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of General Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Thyroid and Breast Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Thyroid and Breast Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Thyroid and Breast Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityAbstract Background Hypothyroidism, a prevalent thyroid hormone abnormality identified by biochemical indicators, is prone to serious consequences because of its insidious clinical manifestations and easy underdiagnosis. This research aimed to elucidate the relationships between indicators of lipid and glucose metabolism and hypothyroidism and to assess the value of metabolic indicators for hypothyroidism. Methods Prevalence surveys were conducted utilizing information from 3254 NHANES individuals who passed screening between 2007 and 2012. Comparisons of baseline characteristics, assessment of logistic regression and subgroup analyses, visualization of restricted cubic splines curves, and validation of causal mediation analyses were performed to obtain a comprehensive view of the relationships between indicators of lipid and glucose metabolism and hypothyroidism. Results Lipid and glucose metabolism indicators, especially the unconventional parameters triglyceride‒glucose index (TyG) and remnant cholesterol (RC) and the conventional parameter triglyceride (TG), exhibited robust positive relationships with hypothyroidism and served as crucial mediators in the pathways by which hypothyroidism affects health outcomes. Indicators were varying suggestive for hypothyroidism in distinct populations, with TyG being relatively more valuable. Conclusions Indicators of lipid and glucose metabolism (TyG, TG, and RC) were intimately associated with hypothyroidism, with potential applications in the assessment and management of hypothyroidism.https://doi.org/10.1186/s12944-025-02457-1Lipid and glucose metabolismIndicatorsHypothyroidismThyroid hormoneNational health and nutrition examination survey |
| spellingShingle | Xinyi Huang Hengzheng Cheng Shuting Wang Laifu Deng Jiaxiu Li An Qin Chunqiang Chu Xiao Liu Associations between indicators of lipid and glucose metabolism and hypothyroidism Lipids in Health and Disease Lipid and glucose metabolism Indicators Hypothyroidism Thyroid hormone National health and nutrition examination survey |
| title | Associations between indicators of lipid and glucose metabolism and hypothyroidism |
| title_full | Associations between indicators of lipid and glucose metabolism and hypothyroidism |
| title_fullStr | Associations between indicators of lipid and glucose metabolism and hypothyroidism |
| title_full_unstemmed | Associations between indicators of lipid and glucose metabolism and hypothyroidism |
| title_short | Associations between indicators of lipid and glucose metabolism and hypothyroidism |
| title_sort | associations between indicators of lipid and glucose metabolism and hypothyroidism |
| topic | Lipid and glucose metabolism Indicators Hypothyroidism Thyroid hormone National health and nutrition examination survey |
| url | https://doi.org/10.1186/s12944-025-02457-1 |
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