Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance

Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance

Background: British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to signif...

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Main Authors: Julia Zöllner, PhD, Binur Orazumbekova, MA, Sam Hodgson, MBBS, David A. van Heel, PhD, Stamatina Iliodromiti, PhD, Moneeza Siddiqui, PhD, Rohini Mathur, PhD, Sarah Finer, PhD, Jennifer Jardine, PhD, Shaheen Akhtar, MSc, Mohammad Anwar, Omar Asgar, MBBS, Samina Ashraf, BSc, Saeed Bidi, PhD, Gerome Breen, PhD, Eamonn Maher, PhD, Daniel MacArthur, PhD, Dan Mason, PhD, Bill Newman, Caroline Winckley, BSc, John Wright, PhD, James Broster, Raymond Chung, BSc, David Collier, PhD, Charles J Curtis, Shabana Chaudhary, MBBS, Grainne Colligan, Panos Deloukas, PhD, Ceri Durham, Faiza Durrani, Fabiola Eto, PhD, Joseph Gafton, MBBS, Ana Angel, MSc, Chris Griffiths, PhD, Joanne Henry, Teng Heng, MD, Qin Qin Huan, Matt Hurles, PhD, Karen A Hunt, PhD, Shapna Hussain, Kamrul Islam, BSc, Vivek Iyer, PhD, Benjamin M Jacobs, PhD, Georgios Kalantzis, PhD, Ahsan Khan, Claudia Langenberg, PhD, Cath Lavery, Sang Hyuck Lee, BSc, Sidra Malik, Daniel Malawsky, Hilary Martin, PhD, Mohammed Bodrul Mazid, John McDermott, Caroline Morton, MBBS, Vladimir Ovchinnikov, PhD, Elizabeth Owor, PhD, Iaroslav Popov, PhD, Asma Qureshi, MSc, Mehru Raza, Jessry Russell, MA, Nishat Safa, Miriam Samuel, MBBS, Michael Simpson, PhD, John Solly, PhD, Marie Spreckley, Daniel Stow, PhD, Michael Taylor, Richard C Trembath, PhD, Karen Tricker, Klaudia Walter, PhD, Suzanne Wood, Sabina Yasmin, Ishevanhu Zengeya, BSc
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:AJOG Global Reports
Subjects:
gestational diabetes
polygenic risk
prediction model
pregnancy complications
prognosis
risk stratification
Online Access:http://www.sciencedirect.com/science/article/pii/S2666577825000188
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