Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance
Background: British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to signif...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | AJOG Global Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666577825000188 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849434050999091200 |
|---|---|
| author | Julia Zöllner, PhD Binur Orazumbekova, MA Sam Hodgson, MBBS David A. van Heel, PhD Stamatina Iliodromiti, PhD Moneeza Siddiqui, PhD Rohini Mathur, PhD Sarah Finer, PhD Jennifer Jardine, PhD Shaheen Akhtar, MSc Mohammad Anwar Omar Asgar, MBBS Samina Ashraf, BSc Saeed Bidi, PhD Gerome Breen, PhD Eamonn Maher, PhD Daniel MacArthur, PhD Dan Mason, PhD Bill Newman Caroline Winckley, BSc John Wright, PhD James Broster Raymond Chung, BSc David Collier, PhD Charles J Curtis Shabana Chaudhary, MBBS Grainne Colligan Panos Deloukas, PhD Ceri Durham Faiza Durrani Fabiola Eto, PhD Joseph Gafton, MBBS Ana Angel, MSc Chris Griffiths, PhD Joanne Henry Teng Heng, MD Qin Qin Huan Matt Hurles, PhD Karen A Hunt, PhD Shapna Hussain Kamrul Islam, BSc Vivek Iyer, PhD Benjamin M Jacobs, PhD Georgios Kalantzis, PhD Ahsan Khan Claudia Langenberg, PhD Cath Lavery Sang Hyuck Lee, BSc Sidra Malik Daniel Malawsky Hilary Martin, PhD Rohini Mathur, PhD Mohammed Bodrul Mazid John McDermott Caroline Morton, MBBS Vladimir Ovchinnikov, PhD Elizabeth Owor, PhD Iaroslav Popov, PhD Asma Qureshi, MSc Mehru Raza Jessry Russell, MA Nishat Safa Miriam Samuel, MBBS Michael Simpson, PhD John Solly, PhD Marie Spreckley Daniel Stow, PhD Michael Taylor Richard C Trembath, PhD Karen Tricker Klaudia Walter, PhD Suzanne Wood Sabina Yasmin Ishevanhu Zengeya, BSc |
| author_facet | Julia Zöllner, PhD Binur Orazumbekova, MA Sam Hodgson, MBBS David A. van Heel, PhD Stamatina Iliodromiti, PhD Moneeza Siddiqui, PhD Rohini Mathur, PhD Sarah Finer, PhD Jennifer Jardine, PhD Shaheen Akhtar, MSc Mohammad Anwar Omar Asgar, MBBS Samina Ashraf, BSc Saeed Bidi, PhD Gerome Breen, PhD Eamonn Maher, PhD Daniel MacArthur, PhD Dan Mason, PhD Bill Newman Caroline Winckley, BSc John Wright, PhD James Broster Raymond Chung, BSc David Collier, PhD Charles J Curtis Shabana Chaudhary, MBBS Grainne Colligan Panos Deloukas, PhD Ceri Durham Faiza Durrani Fabiola Eto, PhD Joseph Gafton, MBBS Ana Angel, MSc Chris Griffiths, PhD Joanne Henry Teng Heng, MD Qin Qin Huan Matt Hurles, PhD Karen A Hunt, PhD Shapna Hussain Kamrul Islam, BSc Vivek Iyer, PhD Benjamin M Jacobs, PhD Georgios Kalantzis, PhD Ahsan Khan Claudia Langenberg, PhD Cath Lavery Sang Hyuck Lee, BSc Sidra Malik Daniel Malawsky Hilary Martin, PhD Rohini Mathur, PhD Mohammed Bodrul Mazid John McDermott Caroline Morton, MBBS Vladimir Ovchinnikov, PhD Elizabeth Owor, PhD Iaroslav Popov, PhD Asma Qureshi, MSc Mehru Raza Jessry Russell, MA Nishat Safa Miriam Samuel, MBBS Michael Simpson, PhD John Solly, PhD Marie Spreckley Daniel Stow, PhD Michael Taylor Richard C Trembath, PhD Karen Tricker Klaudia Walter, PhD Suzanne Wood Sabina Yasmin Ishevanhu Zengeya, BSc |
| author_sort | Julia Zöllner, PhD |
| collection | DOAJ |
| description | Background: British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to significant health complications. Despite this, predictive models tailored to this high-risk, yet understudied group are lacking. Objective: To investigate whether combining genetic and traditional clinical data improves risk prediction of GDM and progression to type 2 diabetes among BPB women. We hypothesized that incorporating polygenic risk scores (PRS) would enhance the predictive accuracy of existing models. Study Design: An observational cohort study utilizing the Genes & Health dataset, which includes comprehensive electronic health records. Women who gave birth between 2000 and 2023, both with and without a history of GDM, were included. Controls were defined as women without a GDM diagnosis during this period but who had a birth record. A total of 117 type 2 diabetes or GDM PRS were tested to determine the optimal PRS based on predictive performance metrics. The best-performing PRS was integrated with clinical variables for statistical analyses, including descriptive statistics, chi-square tests, logistic regression, and receiver operating characteristic curve analysis. Results: Of 13,489 women with birth records, 10,931 were included in the analysis, with 29.3% developing GDM. Women with GDM were older (mean age 31.7 years, P<.001) and had a higher BMI (mean 28.4 kg/m2, P<.001) compared to controls. The optimal PRS demonstrated a strong association with GDM risk; women in the highest PRS decile had significantly increased odds of developing GDM (OR 5.66, 95% CI [4.59, 7.01], P=3.62×10−58). Furthermore, the risk of converting from GDM to type 2 diabetes was 30% in the highest PRS decile, compared to 19% among all GDM cases and 11% in the lowest decile. Incorporating genetic risk factors with clinical data improved the C-statistic for predicting type 2 diabetes following GDM from 0.62 to 0.67 (P=4.58×10−6), indicating better model discrimination. Conclusion: The integration of genetic assessment with traditional clinical factors significantly enhances risk prediction for BPB women at high risk of developing type 2 diabetes after GDM. These findings support the implementation of targeted interventions and personalized monitoring strategies in this high-risk population. Future research should focus on validating these predictive models in external cohorts and exploring their integration into clinical practice to improve health outcomes. |
| format | Article |
| id | doaj-art-56861d11c08f4baaaa85a91eddacad54 |
| institution | Kabale University |
| issn | 2666-5778 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJOG Global Reports |
| spelling | doaj-art-56861d11c08f4baaaa85a91eddacad542025-08-20T03:26:48ZengElsevierAJOG Global Reports2666-57782025-05-015210045710.1016/j.xagr.2025.100457Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a GlanceJulia Zöllner, PhD0Binur Orazumbekova, MA1Sam Hodgson, MBBS2David A. van Heel, PhD3Stamatina Iliodromiti, PhD4Moneeza Siddiqui, PhD5Rohini Mathur, PhD6Sarah Finer, PhD7Jennifer Jardine, PhD8Shaheen Akhtar, MSc9Mohammad Anwar10Omar Asgar, MBBS11Samina Ashraf, BSc12Saeed Bidi, PhD13Gerome Breen, PhD14Eamonn Maher, PhD15Daniel MacArthur, PhD16Dan Mason, PhD17Bill Newman18Caroline Winckley, BSc19John Wright, PhD20James Broster21Raymond Chung, BSc22David Collier, PhD23Charles J Curtis24Shabana Chaudhary, MBBS25Grainne Colligan26Panos Deloukas, PhD27Ceri Durham28Faiza Durrani29Fabiola Eto, PhD30Joseph Gafton, MBBS31Ana Angel, MSc32Chris Griffiths, PhD33Joanne Henry34Teng Heng, MD35Qin Qin Huan36Matt Hurles, PhD37Karen A Hunt, PhD38Shapna Hussain39Kamrul Islam, BSc40Vivek Iyer, PhD41Benjamin M Jacobs, PhD42Georgios Kalantzis, PhD43Ahsan Khan44Claudia Langenberg, PhD45Cath Lavery46Sang Hyuck Lee, BSc47Sidra Malik48Daniel Malawsky49Hilary Martin, PhD50Rohini Mathur, PhD51Mohammed Bodrul Mazid52John McDermott53Caroline Morton, MBBS54Vladimir Ovchinnikov, PhD55Elizabeth Owor, PhD56Iaroslav Popov, PhD57Asma Qureshi, MSc58Mehru Raza59Jessry Russell, MA60Nishat Safa61Miriam Samuel, MBBS62Michael Simpson, PhD63John Solly, PhD64Marie Spreckley65Daniel Stow, PhD66Michael Taylor67Richard C Trembath, PhD68Karen Tricker69Klaudia Walter, PhD70Suzanne Wood71Sabina Yasmin72Ishevanhu Zengeya, BSc73Institute for Women's Health, Population Health Sciences, University College London, London, UK (Zöllner); Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine); Corresponding author: Julia Zöllner, PhD.Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (van Heel)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK (Zöllner, Orazumbekova, Hodgson, Iliodromiti, Siddiqui, Mathur, Finer, and Jardine)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Social Action for Health, London, UK (Anwar, Colligan, and Durham)Manchester University NHS Trust, Manchester, UK (Asgar)Bradford Teaching Hospitals, Bradford, UK (Ashraf)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)University of Cambridge, Cambridge, UK (Maher)Garvan Institute of Medical Research, Darlinghurst, NSW, Australia (MacArthur)Born in Bradford, Bradford, UK (Mason)University of Manchester, Manchester, UK (Newman and McDermott)NIHR Clinical Research Clinical Trials, Manchester, UK (Winckley)Bradford Institute for Health Research, Bradford, UK (Wright)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Social Action for Health, London, UK (Anwar, Colligan, and Durham)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Social Action for Health, London, UK (Anwar, Colligan, and Durham)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)University of Manchester, Manchester, UK (Newman and McDermott)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)King's College London, London, UK (Breen, Chung, Curtis, Hyuck Lee, Simpson, and Trembath)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Wellcome Sanger Institute, London, UK (Akhtar, Heng, Huan, Hurles, Iyer, Kalantzis, Malawsky, Martin, and Walter)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Queen Mary University of London, London, UK (Bidi, Broster, Collier, Chaudhary, Deloukas, Durrani, Eto, Gafton, Angel, Griffiths, Henry, Hunt, Hussain, Islam, Jacobs, Khan, Langenberg, Lavery, Malik, Mathur, Bodrul Mazid, Morton, Ovchinnikov, Owor, Popov, Qureshi, Raza, Russell, Safa, Samuel, Solly, Spreckley, Stow, Taylor, Tricker, Wood, Yasmin, and Zengeya)Background: British Pakistani and Bangladeshi (BPB) women have disproportionately high rates of gestational diabetes mellitus (GDM), with prevalence estimates up to three times higher than in the general population. They are also at increased risk of progressing to type 2 diabetes, leading to significant health complications. Despite this, predictive models tailored to this high-risk, yet understudied group are lacking. Objective: To investigate whether combining genetic and traditional clinical data improves risk prediction of GDM and progression to type 2 diabetes among BPB women. We hypothesized that incorporating polygenic risk scores (PRS) would enhance the predictive accuracy of existing models. Study Design: An observational cohort study utilizing the Genes & Health dataset, which includes comprehensive electronic health records. Women who gave birth between 2000 and 2023, both with and without a history of GDM, were included. Controls were defined as women without a GDM diagnosis during this period but who had a birth record. A total of 117 type 2 diabetes or GDM PRS were tested to determine the optimal PRS based on predictive performance metrics. The best-performing PRS was integrated with clinical variables for statistical analyses, including descriptive statistics, chi-square tests, logistic regression, and receiver operating characteristic curve analysis. Results: Of 13,489 women with birth records, 10,931 were included in the analysis, with 29.3% developing GDM. Women with GDM were older (mean age 31.7 years, P<.001) and had a higher BMI (mean 28.4 kg/m2, P<.001) compared to controls. The optimal PRS demonstrated a strong association with GDM risk; women in the highest PRS decile had significantly increased odds of developing GDM (OR 5.66, 95% CI [4.59, 7.01], P=3.62×10−58). Furthermore, the risk of converting from GDM to type 2 diabetes was 30% in the highest PRS decile, compared to 19% among all GDM cases and 11% in the lowest decile. Incorporating genetic risk factors with clinical data improved the C-statistic for predicting type 2 diabetes following GDM from 0.62 to 0.67 (P=4.58×10−6), indicating better model discrimination. Conclusion: The integration of genetic assessment with traditional clinical factors significantly enhances risk prediction for BPB women at high risk of developing type 2 diabetes after GDM. These findings support the implementation of targeted interventions and personalized monitoring strategies in this high-risk population. Future research should focus on validating these predictive models in external cohorts and exploring their integration into clinical practice to improve health outcomes.http://www.sciencedirect.com/science/article/pii/S2666577825000188gestational diabetespolygenic riskprediction modelpregnancy complicationsprognosisrisk stratification |
| spellingShingle | Julia Zöllner, PhD Binur Orazumbekova, MA Sam Hodgson, MBBS David A. van Heel, PhD Stamatina Iliodromiti, PhD Moneeza Siddiqui, PhD Rohini Mathur, PhD Sarah Finer, PhD Jennifer Jardine, PhD Shaheen Akhtar, MSc Mohammad Anwar Omar Asgar, MBBS Samina Ashraf, BSc Saeed Bidi, PhD Gerome Breen, PhD Eamonn Maher, PhD Daniel MacArthur, PhD Dan Mason, PhD Bill Newman Caroline Winckley, BSc John Wright, PhD James Broster Raymond Chung, BSc David Collier, PhD Charles J Curtis Shabana Chaudhary, MBBS Grainne Colligan Panos Deloukas, PhD Ceri Durham Faiza Durrani Fabiola Eto, PhD Joseph Gafton, MBBS Ana Angel, MSc Chris Griffiths, PhD Joanne Henry Teng Heng, MD Qin Qin Huan Matt Hurles, PhD Karen A Hunt, PhD Shapna Hussain Kamrul Islam, BSc Vivek Iyer, PhD Benjamin M Jacobs, PhD Georgios Kalantzis, PhD Ahsan Khan Claudia Langenberg, PhD Cath Lavery Sang Hyuck Lee, BSc Sidra Malik Daniel Malawsky Hilary Martin, PhD Rohini Mathur, PhD Mohammed Bodrul Mazid John McDermott Caroline Morton, MBBS Vladimir Ovchinnikov, PhD Elizabeth Owor, PhD Iaroslav Popov, PhD Asma Qureshi, MSc Mehru Raza Jessry Russell, MA Nishat Safa Miriam Samuel, MBBS Michael Simpson, PhD John Solly, PhD Marie Spreckley Daniel Stow, PhD Michael Taylor Richard C Trembath, PhD Karen Tricker Klaudia Walter, PhD Suzanne Wood Sabina Yasmin Ishevanhu Zengeya, BSc Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance AJOG Global Reports gestational diabetes polygenic risk prediction model pregnancy complications prognosis risk stratification |
| title | Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance |
| title_full | Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance |
| title_fullStr | Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance |
| title_full_unstemmed | Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance |
| title_short | Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and HealthAJOG MFM at a Glance |
| title_sort | understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from british pakistani and bangladeshi groups a cohort study in genes and healthajog mfm at a glance |
| topic | gestational diabetes polygenic risk prediction model pregnancy complications prognosis risk stratification |
| url | http://www.sciencedirect.com/science/article/pii/S2666577825000188 |
| work_keys_str_mv | AT juliazollnerphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT binurorazumbekovama understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT samhodgsonmbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT davidavanheelphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT stamatinailiodromitiphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT moneezasiddiquiphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT rohinimathurphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT sarahfinerphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT jenniferjardinephd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT shaheenakhtarmsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT mohammadanwar understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT omarasgarmbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT saminaashrafbsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT saeedbidiphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT geromebreenphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT eamonnmaherphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT danielmacarthurphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT danmasonphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT billnewman understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT carolinewinckleybsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT johnwrightphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT jamesbroster understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT raymondchungbsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT davidcollierphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT charlesjcurtis understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT shabanachaudharymbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT grainnecolligan understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT panosdeloukasphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT ceridurham understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT faizadurrani understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT fabiolaetophd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT josephgaftonmbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT anaangelmsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT chrisgriffithsphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT joannehenry understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT tenghengmd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT qinqinhuan understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT matthurlesphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT karenahuntphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT shapnahussain understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT kamrulislambsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT vivekiyerphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT benjaminmjacobsphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT georgioskalantzisphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT ahsankhan understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT claudialangenbergphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT cathlavery understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT sanghyuckleebsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT sidramalik understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT danielmalawsky understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT hilarymartinphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT rohinimathurphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT mohammedbodrulmazid understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT johnmcdermott understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT carolinemortonmbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT vladimirovchinnikovphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT elizabethoworphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT iaroslavpopovphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT asmaqureshimsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT mehruraza understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT jessryrussellma understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT nishatsafa understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT miriamsamuelmbbs understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT michaelsimpsonphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT johnsollyphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT mariespreckley understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT danielstowphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT michaeltaylor understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT richardctrembathphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT karentricker understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT klaudiawalterphd understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT suzannewood understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT sabinayasmin understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance AT ishevanhuzengeyabsc understandingthepotentialcontributionofpolygenicriskscorestothepredictionofgestationalandtype2diabetesinwomenfrombritishpakistaniandbangladeshigroupsacohortstudyingenesandhealthajogmfmataglance |