Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials
Objective: To identify the efficacy of Wolbachia-based intervention by reviewing community-based trials through meta-analysis and systematic review methods. Methods: Studies about Wolbachia-infected mosquito intervention were collected through a screening process. Records underwent data extraction a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtm.apjtm_644_24 |
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| author | Muhammad Afif Naufal Hafsa Hapsari Talitha Dinda Gunawan Robert Sinto |
| author_facet | Muhammad Afif Naufal Hafsa Hapsari Talitha Dinda Gunawan Robert Sinto |
| author_sort | Muhammad Afif Naufal |
| collection | DOAJ |
| description | Objective:
To identify the efficacy of Wolbachia-based intervention by reviewing community-based trials through meta-analysis and systematic review methods.
Methods:
Studies about Wolbachia-infected mosquito intervention were collected through a screening process. Records underwent data extraction and quality assessment independently by the authors. The primary outcome of the study was protective efficacy. Quantitative analysis was conducted through meta-analysis and multivariate meta-regression using Rstudio Ver.2024.09.0-375. Qualitative analysis was done by summarizing records’ findings.
Results:
10 out of the 10 660 records met the criteria. The evidence was moderate in quality and highly heterogeneous. Intervention consisted of releasing Wolbachia-infected Aedes aegypti in densely populated settlements. The combined protective efficacy of Wolbachia intervention against dengue is highly heterogeneous (79%; 95% CI 70-88; I2=98%). wMel strain is significantly more efficacious compared to wAlbB (protective efficacy 84%; 95% CI 76-93; I2=95%) vs. 64% (95% CI 46-82; I2=85%); P<0.01) in preventing dengue cases. Wolbachia-infected mosquito populations were found to be unstable upon release cessation, which necessitated periodic release and monitoring to maintain desired concentration and protective efficacy.
Conclusions:
Wolbachia-based intervention is effective in suppressing the transmission of mosquito-borne diseases, especially dengue, with an excellent safety profile. However, community acceptance and policy remain as significant barriers to implementation. |
| format | Article |
| id | doaj-art-567fc47844cc4d98a6cbad2e089ed79a |
| institution | OA Journals |
| issn | 2352-4146 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj-art-567fc47844cc4d98a6cbad2e089ed79a2025-08-20T02:05:25ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462025-05-0118519720910.4103/apjtm.apjtm_644_24Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trialsMuhammad Afif NaufalHafsa HapsariTalitha Dinda GunawanRobert SintoObjective: To identify the efficacy of Wolbachia-based intervention by reviewing community-based trials through meta-analysis and systematic review methods. Methods: Studies about Wolbachia-infected mosquito intervention were collected through a screening process. Records underwent data extraction and quality assessment independently by the authors. The primary outcome of the study was protective efficacy. Quantitative analysis was conducted through meta-analysis and multivariate meta-regression using Rstudio Ver.2024.09.0-375. Qualitative analysis was done by summarizing records’ findings. Results: 10 out of the 10 660 records met the criteria. The evidence was moderate in quality and highly heterogeneous. Intervention consisted of releasing Wolbachia-infected Aedes aegypti in densely populated settlements. The combined protective efficacy of Wolbachia intervention against dengue is highly heterogeneous (79%; 95% CI 70-88; I2=98%). wMel strain is significantly more efficacious compared to wAlbB (protective efficacy 84%; 95% CI 76-93; I2=95%) vs. 64% (95% CI 46-82; I2=85%); P<0.01) in preventing dengue cases. Wolbachia-infected mosquito populations were found to be unstable upon release cessation, which necessitated periodic release and monitoring to maintain desired concentration and protective efficacy. Conclusions: Wolbachia-based intervention is effective in suppressing the transmission of mosquito-borne diseases, especially dengue, with an excellent safety profile. However, community acceptance and policy remain as significant barriers to implementation.https://journals.lww.com/10.4103/apjtm.apjtm_644_24denguemosquito-borne diseasesmosquitoprimary preventionwolbachia |
| spellingShingle | Muhammad Afif Naufal Hafsa Hapsari Talitha Dinda Gunawan Robert Sinto Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials Asian Pacific Journal of Tropical Medicine dengue mosquito-borne diseases mosquito primary prevention wolbachia |
| title | Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials |
| title_full | Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials |
| title_fullStr | Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials |
| title_full_unstemmed | Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials |
| title_short | Wolbachia-infected mosquito to suppress the transmission chain of mosquito- borne virus: A systematic review and meta—analysis of community-based health intervention trials |
| title_sort | wolbachia infected mosquito to suppress the transmission chain of mosquito borne virus a systematic review and meta analysis of community based health intervention trials |
| topic | dengue mosquito-borne diseases mosquito primary prevention wolbachia |
| url | https://journals.lww.com/10.4103/apjtm.apjtm_644_24 |
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