Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome
ABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. This study aimed to investigate the prognostic value of G-CFR improvement...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011335 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846121316844830720 |
|---|---|
| author | Kai Nogami Masahiro Hoshino Eisuke Usui Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hada Tatsuhiro Nagamine Hiroki Ueno Mirei Setoguchi Tomohiro Tahara Tatsuya Sakamoto Takashi Mineo Tsunekazu Kakuta |
| author_facet | Kai Nogami Masahiro Hoshino Eisuke Usui Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hada Tatsuhiro Nagamine Hiroki Ueno Mirei Setoguchi Tomohiro Tahara Tatsuya Sakamoto Takashi Mineo Tsunekazu Kakuta |
| author_sort | Kai Nogami |
| collection | DOAJ |
| description | ABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. This study aimed to investigate the prognostic value of G-CFR improvement, as evaluated using PC-CMR imaging pre- and post-percutaneous coronary intervention (PCI). Methods: In this single-center study, 320 patients with chronic coronary syndrome (CCS) who underwent pre- and post-PCI PC-CMR measurements were followed up to determine major adverse cardiac or cerebrovascular events (MACCE) predictors. MACCE was defined as a composite of cardiac death, nonfatal myocardial infarction, hospitalization due to heart failure, or ischemic stroke. The association between CMR parameters, including baseline data, G-CFR changes post-PCI, and MACCE, was investigated. Results: G-CFR improvement was observed in 51.6% (165/320) patients, while MACCE occurred in 8.1% (26/320) during a median follow-up period of 2.5 years. G-CFR improvement was significantly associated with a lower pre-PCI G-CFR. The log-rank test revealed a significant association between patients without G-CFR improvement post-PCI and a poor prognosis. Patients with lower pre-PCI G-CFR and lack of G-CFR improvement exhibited the highest incidence of MACCE. The multivariable Cox proportional hazard model revealed that lack of G-CFR improvement was an independently significant MACCE predictor from pre-PCI G-CFR and SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score. Conclusion: Besides the association between pre- and post-PCI lower G-CFR and worse prognosis, the presence or absence of G-CFR improvement post-PCI may provide novel insights into the prognosis following elective PCI in patients with CCS. |
| format | Article |
| id | doaj-art-567ef2e8d2a04c8086921f9eca7097fd |
| institution | Kabale University |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-567ef2e8d2a04c8086921f9eca7097fd2024-12-16T05:34:54ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-01262101106Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndromeKai Nogami0Masahiro Hoshino1Eisuke Usui2Yoshihisa Kanaji3Tomoyo Sugiyama4Masahiro Hada5Tatsuhiro Nagamine6Hiroki Ueno7Mirei Setoguchi8Tomohiro Tahara9Tatsuya Sakamoto10Takashi Mineo11Tsunekazu Kakuta12Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanDivision of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanCorresponding author. Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-1-1 Otsuno, Tsuchiura City, Ibaraki 300-0028, Japan.; Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura City, Ibaraki, JapanABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. This study aimed to investigate the prognostic value of G-CFR improvement, as evaluated using PC-CMR imaging pre- and post-percutaneous coronary intervention (PCI). Methods: In this single-center study, 320 patients with chronic coronary syndrome (CCS) who underwent pre- and post-PCI PC-CMR measurements were followed up to determine major adverse cardiac or cerebrovascular events (MACCE) predictors. MACCE was defined as a composite of cardiac death, nonfatal myocardial infarction, hospitalization due to heart failure, or ischemic stroke. The association between CMR parameters, including baseline data, G-CFR changes post-PCI, and MACCE, was investigated. Results: G-CFR improvement was observed in 51.6% (165/320) patients, while MACCE occurred in 8.1% (26/320) during a median follow-up period of 2.5 years. G-CFR improvement was significantly associated with a lower pre-PCI G-CFR. The log-rank test revealed a significant association between patients without G-CFR improvement post-PCI and a poor prognosis. Patients with lower pre-PCI G-CFR and lack of G-CFR improvement exhibited the highest incidence of MACCE. The multivariable Cox proportional hazard model revealed that lack of G-CFR improvement was an independently significant MACCE predictor from pre-PCI G-CFR and SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score. Conclusion: Besides the association between pre- and post-PCI lower G-CFR and worse prognosis, the presence or absence of G-CFR improvement post-PCI may provide novel insights into the prognosis following elective PCI in patients with CCS.http://www.sciencedirect.com/science/article/pii/S1097664724011335Chronic coronary syndromePercutaneous coronary interventionCardiac magnetic resonanceGlobal coronary flow reserve |
| spellingShingle | Kai Nogami Masahiro Hoshino Eisuke Usui Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hada Tatsuhiro Nagamine Hiroki Ueno Mirei Setoguchi Tomohiro Tahara Tatsuya Sakamoto Takashi Mineo Tsunekazu Kakuta Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome Journal of Cardiovascular Magnetic Resonance Chronic coronary syndrome Percutaneous coronary intervention Cardiac magnetic resonance Global coronary flow reserve |
| title | Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| title_full | Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| title_fullStr | Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| title_full_unstemmed | Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| title_short | Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| title_sort | prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome |
| topic | Chronic coronary syndrome Percutaneous coronary intervention Cardiac magnetic resonance Global coronary flow reserve |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011335 |
| work_keys_str_mv | AT kainogami prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT masahirohoshino prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT eisukeusui prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT yoshihisakanaji prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT tomoyosugiyama prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT masahirohada prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT tatsuhironagamine prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT hirokiueno prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT mireisetoguchi prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT tomohirotahara prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT tatsuyasakamoto prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT takashimineo prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome AT tsunekazukakuta prognosticvalueofglobalcoronaryflowreservebeforeandafterelectivepercutaneouscoronaryinterventioninpatientswithchroniccoronarysyndrome |