The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study
Background and Design: Alopecia areata (AA) is a common, chronic, autoimmune disease that causes psychological effects on patients. Distress and psychological factors play roles in the onset and flares of the disease. We aimed to evaluate the relationship between neurotrophins (NT) and psychological...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-12-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-52711 |
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| author | Hatice Parlak Subaşı Hilal Kaya Erdoğan Ersoy Acer Evin Kocatürk Ali Ercan Altınöz Zeynep Nurhan Saraçoğlu Muzaffer Bilgin |
| author_facet | Hatice Parlak Subaşı Hilal Kaya Erdoğan Ersoy Acer Evin Kocatürk Ali Ercan Altınöz Zeynep Nurhan Saraçoğlu Muzaffer Bilgin |
| author_sort | Hatice Parlak Subaşı |
| collection | DOAJ |
| description | Background and Design: Alopecia areata (AA) is a common, chronic, autoimmune disease that causes psychological effects on patients. Distress and psychological factors play roles in the onset and flares of the disease. We aimed to evaluate the relationship between neurotrophins (NT) and psychological distress in AA patients.
Materials and Methods: The study included 50 AA patients and 50 healthy volunteers as a control group. The Distress Tolerance Scale (DTS) and the Depression Anxiety Stress Scale-21 (DASS-21) were used in the evaluation of psychological distress. Serum levels of NTs [brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] were measured.
Results: Scores of DASS-21 were found to be higher, and scores of DTS were found to be lower in AA patients. Serum BDNF and NT-3 levels did not differ significantly between groups. While the serum NGF level was significantly higher, the NT-4 level was significantly lower in the AA group than in the control group. In the AA group, a similar significant relationship was found between BDNF and stress subscale scores; in the control group, no significant correlation was found between serum NT levels and DASS-21 and DTS scores.
Conclusion: Our study supports the relationship between AA, psychological factors, and NTs. More studies are needed to investigate the relationship between AA and stress neuroimmunology to understand better the common pathophysiology of AA, stress, and various psychiatric diseases. |
| format | Article |
| id | doaj-art-567ecaf848124f4db025dd06e1fcc9ac |
| institution | Kabale University |
| issn | 2651-5164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj-art-567ecaf848124f4db025dd06e1fcc9ac2025-01-07T11:22:03ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642024-12-015849910510.4274/turkderm.galenos.2024.52711TURKDERM-52711The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional studyHatice Parlak Subaşı0Hilal Kaya Erdoğan1Ersoy Acer2Evin Kocatürk3Ali Ercan Altınöz4Zeynep Nurhan Saraçoğlu5Muzaffer Bilgin6Yunus Emre State Hospital, Clinic of Dermatology, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Dermatology, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Dermatology, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Biochemistry, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Psychiatry, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Dermatology, Eskişehir, TürkiyeEskişehir Osmangazi University Faculty of Medicine, Department of Biostatistics, Eskişehir, TürkiyeBackground and Design: Alopecia areata (AA) is a common, chronic, autoimmune disease that causes psychological effects on patients. Distress and psychological factors play roles in the onset and flares of the disease. We aimed to evaluate the relationship between neurotrophins (NT) and psychological distress in AA patients. Materials and Methods: The study included 50 AA patients and 50 healthy volunteers as a control group. The Distress Tolerance Scale (DTS) and the Depression Anxiety Stress Scale-21 (DASS-21) were used in the evaluation of psychological distress. Serum levels of NTs [brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] were measured. Results: Scores of DASS-21 were found to be higher, and scores of DTS were found to be lower in AA patients. Serum BDNF and NT-3 levels did not differ significantly between groups. While the serum NGF level was significantly higher, the NT-4 level was significantly lower in the AA group than in the control group. In the AA group, a similar significant relationship was found between BDNF and stress subscale scores; in the control group, no significant correlation was found between serum NT levels and DASS-21 and DTS scores. Conclusion: Our study supports the relationship between AA, psychological factors, and NTs. More studies are needed to investigate the relationship between AA and stress neuroimmunology to understand better the common pathophysiology of AA, stress, and various psychiatric diseases.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-52711alopecia areataneurotrophinpsychological stress |
| spellingShingle | Hatice Parlak Subaşı Hilal Kaya Erdoğan Ersoy Acer Evin Kocatürk Ali Ercan Altınöz Zeynep Nurhan Saraçoğlu Muzaffer Bilgin The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study Turkderm Turkish Archives of Dermatology and Venereology alopecia areata neurotrophin psychological stress |
| title | The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study |
| title_full | The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study |
| title_fullStr | The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study |
| title_full_unstemmed | The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study |
| title_short | The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study |
| title_sort | relationship between psychological distress and neurotrophins in patients with alopecia areata a crosssectional study |
| topic | alopecia areata neurotrophin psychological stress |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-52711 |
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