Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/9025841 |
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| _version_ | 1850223354199408640 |
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| author | Heng Lu Yi Chen Linlin Li |
| author_facet | Heng Lu Yi Chen Linlin Li |
| author_sort | Heng Lu |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients’ serum. |
| format | Article |
| id | doaj-art-567eb243f75c439face007bdab20f244 |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-567eb243f75c439face007bdab20f2442025-08-20T02:05:59ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/90258419025841Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery DiseaseHeng Lu0Yi Chen1Linlin Li2Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Union Hospital, Fujian Medical University, Fuzhou, ChinaCoronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients’ serum.http://dx.doi.org/10.1155/2018/9025841 |
| spellingShingle | Heng Lu Yi Chen Linlin Li Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease International Journal of Genomics |
| title | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
| title_full | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
| title_fullStr | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
| title_full_unstemmed | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
| title_short | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
| title_sort | metabolic pathway genes associated with susceptibility genes to coronary artery disease |
| url | http://dx.doi.org/10.1155/2018/9025841 |
| work_keys_str_mv | AT henglu metabolicpathwaygenesassociatedwithsusceptibilitygenestocoronaryarterydisease AT yichen metabolicpathwaygenesassociatedwithsusceptibilitygenestocoronaryarterydisease AT linlinli metabolicpathwaygenesassociatedwithsusceptibilitygenestocoronaryarterydisease |