Single-cell RNA sequencing reveals important role of monocytes and macrophages during mucopolysaccharidosis treatment

Single-cell RNA sequencing reveals important role of monocytes and macrophages during mucopolysaccharidosis treatment

Abstract Mucopolysaccharidosis (MPS) encompasses a heterogeneous group of lysosomal storage diseases resulting from mutations in genes encoding lysosomal enzymes responsible for the degradation of mucopolysaccharides, also known as glycosaminoglycans (GAGs). Current therapeutic strategies for MPS in...

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Bibliographic Details
Main Authors: Gaohui Zhu, Yue Xie, Li Li, Rong Li, Yihong Sun, Ting Zhou, Yupeng Cun
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Type II mucopolysaccharidosis
Enzyme replacement therapy
Single-cell RNA sequencing
T-cell receptor sequencing
Whole-genome sequencing
Online Access:https://doi.org/10.1038/s41598-025-97330-7
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