Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children

Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children

ABSTRACT Background Langerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAFV600E mut...

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Bibliographic Details
Main Authors: Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Cancer Medicine
Subjects:
BRAF
children
clinical features
Langerhans cell histiocytosis
MA2PK1
Online Access:https://doi.org/10.1002/cam4.70532
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