Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria
Objective: Tuberculosis remains a significant public health concern as a communicable disease. This study investigated CD4+ counts and hematological parameters in patients infected with Mycobacterium tuberculosis. Methods: M. tuberculosis detection was performed using GeneXpert MTB/RIF, while CD4+...
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Universidad Nacional Hermilio Valdizán de Huánuco
2025-03-01
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| Series: | Microbes, Infection and Chemotherapy |
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| Online Access: | https://revistas.unheval.edu.pe/index.php/mic/article/view/2286 |
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| author | James Hamuel Doughari Isaiac Kadala Fatima Hamza |
| author_facet | James Hamuel Doughari Isaiac Kadala Fatima Hamza |
| author_sort | James Hamuel Doughari |
| collection | DOAJ |
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Objective: Tuberculosis remains a significant public health concern as a communicable disease. This study investigated CD4+ counts and hematological parameters in patients infected with Mycobacterium tuberculosis. Methods: M. tuberculosis detection was performed using GeneXpert MTB/RIF, while CD4+ counts and hematological parameters were analyzed using BD FACS Count and SYSMEX, respectively. Results: Mycobacterium tuberculosis strain L-form, M. tuberculosis strain H83, and M. tuberculosis strain bj were identified in all hospitals surveyed. The mean CD4+ count was significantly lower in M. tuberculosis-positive patients (521.4 ± 2.3) compared to the healthy control group (936 ± 0.43) (p < 0.05). Conversely, infected patients exhibited significantly higher mean leukocyte (18.3 ± 1.03 × 109/L, p = 0.001) and erythrocyte sedimentation rate (98.6 ± 21.00 mm/hr, p = 0.002) compared to controls (4.2 ± 06.3 × 109/L and 8.7 ± 2.10 mm/hr, respectively). Mean hemoglobin levels were lower in infected patients (8.6 ± 2.30) than in controls (15.3 ± 0.01), whereas the mean platelet count was significantly higher in infected patients (602.1 ± 2.70, p = 0.001) compared to the control group (312 ± 2.02). Conclusion: A baseline assessment of immunohematological parameters should be conducted in all M. tuberculosis-positive patients before initiating anti-TB therapy. Additionally, public health education on reducing exposure to TB risk factors is essential.
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| format | Article |
| id | doaj-art-5674b7efa1b24fc292a54bddb29b37d0 |
| institution | DOAJ |
| issn | 2789-4274 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Universidad Nacional Hermilio Valdizán de Huánuco |
| record_format | Article |
| series | Microbes, Infection and Chemotherapy |
| spelling | doaj-art-5674b7efa1b24fc292a54bddb29b37d02025-08-20T02:59:28ZengUniversidad Nacional Hermilio Valdizán de HuánucoMicrobes, Infection and Chemotherapy2789-42742025-03-01510.54034/mic.e2286Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, NigeriaJames Hamuel Doughari0https://orcid.org/0000-0002-6048-7602Isaiac Kadala1Fatima Hamza2Department of Microbiology, Faculty of Life Sciences, Modibbo Adama University, PMB 2076, Yola, NigeriaDepartment of Public Health, Adamawa State Ministry of Health, Yola, NigeriaDepartment of Microbiology, Faculty of Life Sciences, Modibbo Adama University, PMB 2076, Yola, Nigeria Objective: Tuberculosis remains a significant public health concern as a communicable disease. This study investigated CD4+ counts and hematological parameters in patients infected with Mycobacterium tuberculosis. Methods: M. tuberculosis detection was performed using GeneXpert MTB/RIF, while CD4+ counts and hematological parameters were analyzed using BD FACS Count and SYSMEX, respectively. Results: Mycobacterium tuberculosis strain L-form, M. tuberculosis strain H83, and M. tuberculosis strain bj were identified in all hospitals surveyed. The mean CD4+ count was significantly lower in M. tuberculosis-positive patients (521.4 ± 2.3) compared to the healthy control group (936 ± 0.43) (p < 0.05). Conversely, infected patients exhibited significantly higher mean leukocyte (18.3 ± 1.03 × 109/L, p = 0.001) and erythrocyte sedimentation rate (98.6 ± 21.00 mm/hr, p = 0.002) compared to controls (4.2 ± 06.3 × 109/L and 8.7 ± 2.10 mm/hr, respectively). Mean hemoglobin levels were lower in infected patients (8.6 ± 2.30) than in controls (15.3 ± 0.01), whereas the mean platelet count was significantly higher in infected patients (602.1 ± 2.70, p = 0.001) compared to the control group (312 ± 2.02). Conclusion: A baseline assessment of immunohematological parameters should be conducted in all M. tuberculosis-positive patients before initiating anti-TB therapy. Additionally, public health education on reducing exposure to TB risk factors is essential. https://revistas.unheval.edu.pe/index.php/mic/article/view/2286CD4+ counterythrocyte sedimentation rateGeneXpertHaemoglobinhematologicalMycobacterium tuberculosis |
| spellingShingle | James Hamuel Doughari Isaiac Kadala Fatima Hamza Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria Microbes, Infection and Chemotherapy CD4+ count erythrocyte sedimentation rate GeneXpert Haemoglobin hematological Mycobacterium tuberculosis |
| title | Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria |
| title_full | Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria |
| title_fullStr | Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria |
| title_full_unstemmed | Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria |
| title_short | Haematological Alterations and CD4+ Count in Patients with Mycobacterium tuberculosis and HIV coinfection in Adamawa, Nigeria |
| title_sort | haematological alterations and cd4 count in patients with mycobacterium tuberculosis and hiv coinfection in adamawa nigeria |
| topic | CD4+ count erythrocyte sedimentation rate GeneXpert Haemoglobin hematological Mycobacterium tuberculosis |
| url | https://revistas.unheval.edu.pe/index.php/mic/article/view/2286 |
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