Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas
Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2673-7523/4/4/30 |
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| author | Simon L. Barry Emer Lynch Philip Bredin Sebastian McWilliams Julie McCarthy Orla O’Mahony Linda Feeley Killian Nugent Patrick Sheahan Deirdre O’Hanlon David O’Reilly Seamus O’Reilly |
| author_facet | Simon L. Barry Emer Lynch Philip Bredin Sebastian McWilliams Julie McCarthy Orla O’Mahony Linda Feeley Killian Nugent Patrick Sheahan Deirdre O’Hanlon David O’Reilly Seamus O’Reilly |
| author_sort | Simon L. Barry |
| collection | DOAJ |
| description | Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians. |
| format | Article |
| id | doaj-art-566ca5c2df34438e99af4d01e02e1103 |
| institution | DOAJ |
| issn | 2673-7523 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Onco |
| spelling | doaj-art-566ca5c2df34438e99af4d01e02e11032025-08-20T02:57:28ZengMDPI AGOnco2673-75232024-12-014442743810.3390/onco4040030Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic AreasSimon L. Barry0Emer Lynch1Philip Bredin2Sebastian McWilliams3Julie McCarthy4Orla O’Mahony5Linda Feeley6Killian Nugent7Patrick Sheahan8Deirdre O’Hanlon9David O’Reilly10Seamus O’Reilly11Department of Medical Oncology and UCC Cancer Clinical Trials Group, Cork University Hospital, Cork, IrelandDepartment of Medical Oncology and UCC Cancer Clinical Trials Group, Cork University Hospital, Cork, IrelandDepartment of Medical Oncology and UCC Cancer Clinical Trials Group, Cork University Hospital, Cork, IrelandDepartment of Radiology, South Infirmary Victoria University Hospital, Cork, IrelandDepartment of Histopathology, South Infirmary Victoria University Hospital, Cork, IrelandDepartment of Histopathology, South Infirmary Victoria University Hospital, Cork, IrelandDepartment of Histopathology, South Infirmary Victoria University Hospital, Cork, IrelandDepartment of Radiotherapy, Cork University Hospital, Cork, IrelandENTO Research Unit, School of Medicine and Health, University College Cork, Cork, IrelandDepartment of General/Breast Surgery, South Infirmary Victoria University Hospital, Cork, IrelandBeaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, IrelandDepartment of Medical Oncology and UCC Cancer Clinical Trials Group, Cork University Hospital, Cork, IrelandAnaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.https://www.mdpi.com/2673-7523/4/4/30anaplastic thyroid carcinomatargeted therapyperforationcomplications |
| spellingShingle | Simon L. Barry Emer Lynch Philip Bredin Sebastian McWilliams Julie McCarthy Orla O’Mahony Linda Feeley Killian Nugent Patrick Sheahan Deirdre O’Hanlon David O’Reilly Seamus O’Reilly Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas Onco anaplastic thyroid carcinoma targeted therapy perforation complications |
| title | Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| title_full | Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| title_fullStr | Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| title_full_unstemmed | Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| title_short | Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| title_sort | visceral perforation complicating braf mek targeted therapy of papillary thyroid carcinoma with anaplastic areas |
| topic | anaplastic thyroid carcinoma targeted therapy perforation complications |
| url | https://www.mdpi.com/2673-7523/4/4/30 |
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