Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissu...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/619583 |
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| author | Dilip Dey Gregory R. D. Evans |
| author_facet | Dilip Dey Gregory R. D. Evans |
| author_sort | Dilip Dey |
| collection | DOAJ |
| description | During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed. |
| format | Article |
| id | doaj-art-5664e65ceea34442a04d4cd1b41a6097 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5664e65ceea34442a04d4cd1b41a60972025-02-03T07:25:31ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/619583619583Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear ReprogrammingDilip Dey0Gregory R. D. Evans1Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, CA 92868, USAAesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, CA 92868, USADuring embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyte but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review article, different aspects of nuclear reprogramming are discussed.http://dx.doi.org/10.4061/2011/619583 |
| spellingShingle | Dilip Dey Gregory R. D. Evans Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming Stem Cells International |
| title | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
| title_full | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
| title_fullStr | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
| title_full_unstemmed | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
| title_short | Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming |
| title_sort | generation of induced pluripotent stem ips cells by nuclear reprogramming |
| url | http://dx.doi.org/10.4061/2011/619583 |
| work_keys_str_mv | AT dilipdey generationofinducedpluripotentstemipscellsbynuclearreprogramming AT gregoryrdevans generationofinducedpluripotentstemipscellsbynuclearreprogramming |