Innate Pathways of Immune Activation in Transplantation
Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells. Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutionarily primitive pathways, have demonstrated...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2010/826240 |
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| _version_ | 1850223407824633856 |
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| author | Todd V. Brennan Keri E. Lunsford Paul C. Kuo |
| author_facet | Todd V. Brennan Keri E. Lunsford Paul C. Kuo |
| author_sort | Todd V. Brennan |
| collection | DOAJ |
| description | Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells. Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutionarily primitive pathways, have demonstrated a critical role of the innate immune system in the regulation of the adaptive immune system. Innate immunity has been extensively studied in its role as the host's first-line defense against microbial pathogens; however, it is becoming increasingly recognized for its ability to also recognize host-derived molecules that result from tissue damage. The capacity of endogenous damage signals acting through the innate immune system to lower immune thresholds and promote immune recognition and rejection of transplant grafts is only beginning to be appreciated. An improved understanding of these pathways may reveal novel therapeutic targets to decrease graft alloreactivity and increase graft longevity. |
| format | Article |
| id | doaj-art-565e746c0cc74fc5ada013cd038021d3 |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-565e746c0cc74fc5ada013cd038021d32025-08-20T02:05:57ZengWileyJournal of Transplantation2090-00072090-00152010-01-01201010.1155/2010/826240826240Innate Pathways of Immune Activation in TransplantationTodd V. Brennan0Keri E. Lunsford1Paul C. Kuo2Division of Transplantation, Department of Surgery, Duke University Medical Center, P.O. Box 3512, Durham, NC 27710, USADepartment of Surgery, Duke University Medical Center, P.O. Box 3512, Durham, NC 27710, USADivision of Transplantation, Department of Surgery, Duke University Medical Center, P.O. Box 3512, Durham, NC 27710, USAStudies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells. Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutionarily primitive pathways, have demonstrated a critical role of the innate immune system in the regulation of the adaptive immune system. Innate immunity has been extensively studied in its role as the host's first-line defense against microbial pathogens; however, it is becoming increasingly recognized for its ability to also recognize host-derived molecules that result from tissue damage. The capacity of endogenous damage signals acting through the innate immune system to lower immune thresholds and promote immune recognition and rejection of transplant grafts is only beginning to be appreciated. An improved understanding of these pathways may reveal novel therapeutic targets to decrease graft alloreactivity and increase graft longevity.http://dx.doi.org/10.1155/2010/826240 |
| spellingShingle | Todd V. Brennan Keri E. Lunsford Paul C. Kuo Innate Pathways of Immune Activation in Transplantation Journal of Transplantation |
| title | Innate Pathways of Immune Activation in Transplantation |
| title_full | Innate Pathways of Immune Activation in Transplantation |
| title_fullStr | Innate Pathways of Immune Activation in Transplantation |
| title_full_unstemmed | Innate Pathways of Immune Activation in Transplantation |
| title_short | Innate Pathways of Immune Activation in Transplantation |
| title_sort | innate pathways of immune activation in transplantation |
| url | http://dx.doi.org/10.1155/2010/826240 |
| work_keys_str_mv | AT toddvbrennan innatepathwaysofimmuneactivationintransplantation AT kerielunsford innatepathwaysofimmuneactivationintransplantation AT paulckuo innatepathwaysofimmuneactivationintransplantation |