Caffeic Acid and Erythromycin: Antibacterial and Synergistic Effects on Staphylococci
<b>Background:</b> Antibiotic-resistant bacteria, especially <i>Staphylococcus</i> species, are a growing concern in healthcare settings and infections caused by multidrug-resistant strains are difficult to treat. Therefore, it is imperative to explore new treatment methods f...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/7/964 |
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| Summary: | <b>Background:</b> Antibiotic-resistant bacteria, especially <i>Staphylococcus</i> species, are a growing concern in healthcare settings and infections caused by multidrug-resistant strains are difficult to treat. Therefore, it is imperative to explore new treatment methods for these infections such as combinations of natural compounds with antibiotics. <b>Methods:</b> The main objective of this study was to investigate the antimicrobial activity of caffeic acid against staphylococcal strains. The viability of bacterial cells and half maximal inhibitory concentration (IC<sub>50</sub>) for caffeic acid were also examined. The minimum inhibitory concentration (MIC) of the caffeic acid was determined using a serial microdilution method. To study the combined effect of caffeic acid and erythromycin, the fractional inhibitory concentrations (FICs) were determined. <b>Results:</b> Caffeic acid inhibited the growth of all the tested isolates, with MIC values ranging from 256 to 1024 µg/mL and reduced bacterial cell viability at concentrations corresponding to MIC values. Caffeic acid and erythromycin showed a synergistic effect when used together against three examined strains and had an additive effect against two isolates. However, their combination was indifferent against the seven remaining staphylococci tested. <b>Conclusions:</b> The results of our research demonstrate that caffeic acid has antimicrobial properties against the tested strains. |
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| ISSN: | 1424-8247 |