Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’
Summary: In this issue, Hyslop and colleagues discuss challenges leading to inadequate enrolment and premature termination of the MAGIC trial, a multicentre randomised controlled trial of melatonin vs midazolam premedication for anxiety among children. The authors should be commended for sharing the...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | BJA Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772609625000334 |
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| author | Tori N. Sutherland Paul A. Stricker Andrew J. Davidson |
| author_facet | Tori N. Sutherland Paul A. Stricker Andrew J. Davidson |
| author_sort | Tori N. Sutherland |
| collection | DOAJ |
| description | Summary: In this issue, Hyslop and colleagues discuss challenges leading to inadequate enrolment and premature termination of the MAGIC trial, a multicentre randomised controlled trial of melatonin vs midazolam premedication for anxiety among children. The authors should be commended for sharing their experiences, as they underscore common pitfalls of well-intended trials in the perioperative setting, including issues with study design and implementation. |
| format | Article |
| id | doaj-art-5658fc82b47e4131bf6127245aaeffd9 |
| institution | DOAJ |
| issn | 2772-6096 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BJA Open |
| spelling | doaj-art-5658fc82b47e4131bf6127245aaeffd92025-08-20T03:14:38ZengElsevierBJA Open2772-60962025-06-011410040910.1016/j.bjao.2025.100409Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’Tori N. Sutherland0Paul A. Stricker1Andrew J. Davidson2Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia (CHOP), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Center for Clinical Futures, CHOP Research Institute, Philadelphia, PA, USA; Corresponding author.Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia (CHOP), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USADepartment of Anaesthesia, Royal Children's Hospital, Melbourne, VIC, Australia; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia; Melbourne Children's Trials Centre, Murdoch Children's Research Institute, Melbourne, VIC, AustraliaSummary: In this issue, Hyslop and colleagues discuss challenges leading to inadequate enrolment and premature termination of the MAGIC trial, a multicentre randomised controlled trial of melatonin vs midazolam premedication for anxiety among children. The authors should be commended for sharing their experiences, as they underscore common pitfalls of well-intended trials in the perioperative setting, including issues with study design and implementation.http://www.sciencedirect.com/science/article/pii/S2772609625000334enrollment challengesMAGIC trialpaediatric clinical trials |
| spellingShingle | Tori N. Sutherland Paul A. Stricker Andrew J. Davidson Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ BJA Open enrollment challenges MAGIC trial paediatric clinical trials |
| title | Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ |
| title_full | Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ |
| title_fullStr | Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ |
| title_full_unstemmed | Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ |
| title_short | Common pitfalls of perioperative clinical trials in response to ‘Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)’ |
| title_sort | common pitfalls of perioperative clinical trials in response to barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children the magic trial |
| topic | enrollment challenges MAGIC trial paediatric clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S2772609625000334 |
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