New insights into mesenchymal stem cells in inflammatory subtypes of asthma
Asthma is a heterogeneous disease characterized by chronic airway inflammation, heightened reactivity, and structural remodeling. The responses of different phenotypes to traditional corticosteroid therapy vary significantly, with steroid resistance in low T-helper type 2 asthma remaining an urgent...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649597/full |
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| author | Zheng-yan Hou Yu-qiu Hao Lin Zhang Wei Li Peng Gao |
| author_facet | Zheng-yan Hou Yu-qiu Hao Lin Zhang Wei Li Peng Gao |
| author_sort | Zheng-yan Hou |
| collection | DOAJ |
| description | Asthma is a heterogeneous disease characterized by chronic airway inflammation, heightened reactivity, and structural remodeling. The responses of different phenotypes to traditional corticosteroid therapy vary significantly, with steroid resistance in low T-helper type 2 asthma remaining an urgent clinical challenge. In recent years, mesenchymal stem cells (MSCs) and their exosomes—mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)—have emerged as promising therapeutic agents due to their potent immunomodulatory properties. In this review, we systematically explain how MSCs and MSC-EVs inhibit airway inflammation in asthma through multi-target immunoregulation, highlight their therapeutic potential in steroid-resistant asthma, and outline the challenges and optimization strategies involved in clinical translation, thereby providing a theoretical foundation for the development of novel therapies. |
| format | Article |
| id | doaj-art-56583c1884bb4537863c0aaba40778dc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-56583c1884bb4537863c0aaba40778dc2025-08-26T04:12:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16495971649597New insights into mesenchymal stem cells in inflammatory subtypes of asthmaZheng-yan HouYu-qiu HaoLin ZhangWei LiPeng GaoAsthma is a heterogeneous disease characterized by chronic airway inflammation, heightened reactivity, and structural remodeling. The responses of different phenotypes to traditional corticosteroid therapy vary significantly, with steroid resistance in low T-helper type 2 asthma remaining an urgent clinical challenge. In recent years, mesenchymal stem cells (MSCs) and their exosomes—mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)—have emerged as promising therapeutic agents due to their potent immunomodulatory properties. In this review, we systematically explain how MSCs and MSC-EVs inhibit airway inflammation in asthma through multi-target immunoregulation, highlight their therapeutic potential in steroid-resistant asthma, and outline the challenges and optimization strategies involved in clinical translation, thereby providing a theoretical foundation for the development of novel therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649597/fullasthmainflammationmesenchymal stem cellsexosomesimmunomodulationcell-based therapy |
| spellingShingle | Zheng-yan Hou Yu-qiu Hao Lin Zhang Wei Li Peng Gao New insights into mesenchymal stem cells in inflammatory subtypes of asthma Frontiers in Immunology asthma inflammation mesenchymal stem cells exosomes immunomodulation cell-based therapy |
| title | New insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| title_full | New insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| title_fullStr | New insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| title_full_unstemmed | New insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| title_short | New insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| title_sort | new insights into mesenchymal stem cells in inflammatory subtypes of asthma |
| topic | asthma inflammation mesenchymal stem cells exosomes immunomodulation cell-based therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649597/full |
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