Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances
Irritable bowel syndrome (IBS) is an extremely common chronic intestinal disorder characterized by recurrent abdominal pain and altered bowel habits, significantly impacting patients' quality of life. The etiology of IBS remains incompletely understood. Research has identified low-grade intesti...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-03-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0491 |
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| author | LIU Li ZHAO Chunhua MIN Han |
| author_facet | LIU Li ZHAO Chunhua MIN Han |
| author_sort | LIU Li |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is an extremely common chronic intestinal disorder characterized by recurrent abdominal pain and altered bowel habits, significantly impacting patients' quality of life. The etiology of IBS remains incompletely understood. Research has identified low-grade intestinal inflammation and immune activation, primarily manifested as an imbalance between pro-inflammatory and anti-inflammatory cytokines, as key pathogenic mechanisms in IBS. Among these, interleukin-6 (IL-6), a core pro-inflammatory cytokine, is significantly elevated in IBS patients. IL-6 contributes to the pathogenesis of IBS through various mechanisms, including altering individual susceptibility to IBS, promoting gastrointestinal motility and secretion, activating the hypothalamic-pituitary-adrenal axis, inducing visceral hypersensitivity, and impairing intestinal mucosal barrier function. Furthermore, IL-6 levels are closely associated with the severity of IBS symptoms. This review summarizes the role and mechanisms of IL-6 in IBS, aiming to provide insights and references for clinicians and researchers investigating the etiology of IBS. |
| format | Article |
| id | doaj-art-56582cd303124ba5877d8a9e8ec3bec7 |
| institution | OA Journals |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-56582cd303124ba5877d8a9e8ec3bec72025-08-20T02:12:10ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-03-0116243143810.12290/xhyxzz.2024-0491Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research AdvancesLIU Li0ZHAO Chunhua1MIN HanDepartment of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital, Suzhou Women and Children's Heath Hospital), Suzhou, Jiangsu 215001, ChinaMedical Big Data Center, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital, Suzhou Women and Children's Heath Hospital), Suzhou, Jiangsu 215001, ChinaIrritable bowel syndrome (IBS) is an extremely common chronic intestinal disorder characterized by recurrent abdominal pain and altered bowel habits, significantly impacting patients' quality of life. The etiology of IBS remains incompletely understood. Research has identified low-grade intestinal inflammation and immune activation, primarily manifested as an imbalance between pro-inflammatory and anti-inflammatory cytokines, as key pathogenic mechanisms in IBS. Among these, interleukin-6 (IL-6), a core pro-inflammatory cytokine, is significantly elevated in IBS patients. IL-6 contributes to the pathogenesis of IBS through various mechanisms, including altering individual susceptibility to IBS, promoting gastrointestinal motility and secretion, activating the hypothalamic-pituitary-adrenal axis, inducing visceral hypersensitivity, and impairing intestinal mucosal barrier function. Furthermore, IL-6 levels are closely associated with the severity of IBS symptoms. This review summarizes the role and mechanisms of IL-6 in IBS, aiming to provide insights and references for clinicians and researchers investigating the etiology of IBS.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0491irritable bowel syndromelow-grade intestinal inflammationpro-inflammatory cytokinesinterleukin-6 |
| spellingShingle | LIU Li ZHAO Chunhua MIN Han Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances Xiehe Yixue Zazhi irritable bowel syndrome low-grade intestinal inflammation pro-inflammatory cytokines interleukin-6 |
| title | Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances |
| title_full | Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances |
| title_fullStr | Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances |
| title_full_unstemmed | Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances |
| title_short | Interleukin-6 and Irritable Bowel Syndrome: Mechanisms and Research Advances |
| title_sort | interleukin 6 and irritable bowel syndrome mechanisms and research advances |
| topic | irritable bowel syndrome low-grade intestinal inflammation pro-inflammatory cytokines interleukin-6 |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0491 |
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