Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns
Aim. To determine among infants born before the 28th week of gestation to what extent blood gas abnormalities during the first three postnatal days provide information about the risk of bronchopulmonary dysplasia (BPD). Methods. We studied the association of extreme quartiles of blood gas measuremen...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/210218 |
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| author | Sudhir Sriram Joy Condie Michael D. Schreiber Daniel G. Batton Bhavesh Shah Carl Bose Matthew Laughon Linda J. Van Marter Elizabeth N. Allred Alan Leviton |
| author_facet | Sudhir Sriram Joy Condie Michael D. Schreiber Daniel G. Batton Bhavesh Shah Carl Bose Matthew Laughon Linda J. Van Marter Elizabeth N. Allred Alan Leviton |
| author_sort | Sudhir Sriram |
| collection | DOAJ |
| description | Aim. To determine among infants born before the 28th week of gestation to what extent blood gas abnormalities during the first three postnatal days provide information about the risk of bronchopulmonary dysplasia (BPD). Methods. We studied the association of extreme quartiles of blood gas measurements (hypoxemia, hyperoxemia, hypocapnea, and hypercapnea) in the first three postnatal days, with bronchopulmonary dysplasia, among 906 newborns, using multivariable models adjusting for potential confounders. We approximated NIH criteria by classifying severity of BPD on the basis of the receipt of any O2 on postnatal day 28 and at 36 weeks PMA and assisted ventilation. Results. In models that did not adjust for ventilation, hypoxemia was associated with increased risk of severe BPD and very severe BPD, while infants who had hypercapnea were at increased risk of very severe BPD only. In contrast, infants who had hypocapnea were at reduced risk of severe BPD. Including ventilation for 14 or more days eliminated the associations with hypoxemia and with hypercapnea and made the decreased risk of very severe BPD statistically significant. Conclusions. Among ELGANs, recurrent/persistent blood gas abnormalities in the first three postnatal days convey information about the risk of severe and very severe BPD. |
| format | Article |
| id | doaj-art-5654415b288847319f52410a4984e25c |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-5654415b288847319f52410a4984e25c2025-02-03T05:58:35ZengWileyInternational Journal of Pediatrics1687-97401687-97592014-01-01201410.1155/2014/210218210218Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age NewbornsSudhir Sriram0Joy Condie1Michael D. Schreiber2Daniel G. Batton3Bhavesh Shah4Carl Bose5Matthew Laughon6Linda J. Van Marter7Elizabeth N. Allred8Alan Leviton9Department of Pediatrics, University of Chicago, 5841 South Maryland Avenue MC 6060, Chicago, IL 60637, USADepartment of Pediatrics, University of Chicago, 5841 South Maryland Avenue MC 6060, Chicago, IL 60637, USADepartment of Pediatrics, University of Chicago, 5841 South Maryland Avenue MC 6060, Chicago, IL 60637, USADepartment of Pediatrics, Southern Illinois School of Medicine, 301 North 8th Street, Springfield, IL 62794, USADepartment of Pediatrics, Bay State Medical Center, 759 Chestnut Street, Springfield, MA 01199, USADepartment of Pediatrics, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27599, USADepartment of Pediatrics, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27599, USADepartment of Pediatrics, Harvard Medical School, 220 Longwood Drive, Boston, MA 02115, USADepartment of Neurology, Harvard Medical School, 220 Longwood Drive, Boston, MA 02115, USADepartment of Neurology, Harvard Medical School, 220 Longwood Drive, Boston, MA 02115, USAAim. To determine among infants born before the 28th week of gestation to what extent blood gas abnormalities during the first three postnatal days provide information about the risk of bronchopulmonary dysplasia (BPD). Methods. We studied the association of extreme quartiles of blood gas measurements (hypoxemia, hyperoxemia, hypocapnea, and hypercapnea) in the first three postnatal days, with bronchopulmonary dysplasia, among 906 newborns, using multivariable models adjusting for potential confounders. We approximated NIH criteria by classifying severity of BPD on the basis of the receipt of any O2 on postnatal day 28 and at 36 weeks PMA and assisted ventilation. Results. In models that did not adjust for ventilation, hypoxemia was associated with increased risk of severe BPD and very severe BPD, while infants who had hypercapnea were at increased risk of very severe BPD only. In contrast, infants who had hypocapnea were at reduced risk of severe BPD. Including ventilation for 14 or more days eliminated the associations with hypoxemia and with hypercapnea and made the decreased risk of very severe BPD statistically significant. Conclusions. Among ELGANs, recurrent/persistent blood gas abnormalities in the first three postnatal days convey information about the risk of severe and very severe BPD.http://dx.doi.org/10.1155/2014/210218 |
| spellingShingle | Sudhir Sriram Joy Condie Michael D. Schreiber Daniel G. Batton Bhavesh Shah Carl Bose Matthew Laughon Linda J. Van Marter Elizabeth N. Allred Alan Leviton Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns International Journal of Pediatrics |
| title | Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns |
| title_full | Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns |
| title_fullStr | Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns |
| title_full_unstemmed | Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns |
| title_short | Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns |
| title_sort | early blood gas predictors of bronchopulmonary dysplasia in extremely low gestational age newborns |
| url | http://dx.doi.org/10.1155/2014/210218 |
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