Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults

Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults

α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. This study investigated the relationship between urinary metal concentrations and serum α-Klo...

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Bibliographic Details
Main Authors: Xinliang Zheng, Wenxin Zhou, Zhuoying Jiang, Chan Ding, Minqian Feng, Yongxin Li, Fitri Kurniasari, Shuanghua Xie, Huadong Xu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Toxics
Subjects:
α-Klotho
urinary metals
NHANES
metal mixtures
aging biomarkers
Online Access:https://www.mdpi.com/2305-6304/13/4/237
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