Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults
α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. This study investigated the relationship between urinary metal concentrations and serum α-Klo...
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MDPI AG
2025-03-01
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| author | Xinliang Zheng Wenxin Zhou Zhuoying Jiang Chan Ding Minqian Feng Yongxin Li Fitri Kurniasari Shuanghua Xie Huadong Xu |
| author_facet | Xinliang Zheng Wenxin Zhou Zhuoying Jiang Chan Ding Minqian Feng Yongxin Li Fitri Kurniasari Shuanghua Xie Huadong Xu |
| author_sort | Xinliang Zheng |
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| description | α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. This study investigated the relationship between urinary metal concentrations and serum α-Klotho levels using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2016 cycles. A total of 4071 adults aged 40 to 79 years were included in the analysis. After adjusting for potential confounders, positive associations were found between serum α-Klotho levels and barium (Ba), cesium (Cs), and molybdenum (Mo), while tungsten (W) and uranium (U) were negatively correlated with α-Klotho levels. The combined effects of multiple metals were further analyzed using the qgcomp model, which demonstrated a negative correlation between increased metal mixtures and serum α-Klotho levels. Specifically, U, total arsenic (t-As), W, cadmium (Cd), antimony (Sb), and lead (Pb) contributed to the reduction of α-Klotho levels, while Ba, Cs, dimethylarsinic acid (DMA), Mo, thallium (Tl), and cobalt (Co) were positively associated with α-Klotho levels. These findings suggest that exposure to certain metals, particularly in combination, may reduce serum α-Klotho levels, potentially accelerating aging processes. Further studies should investigate the underlying mechanisms responsible for these associations. |
| format | Article |
| id | doaj-art-564abd59010043ee9600d7ff5e7f711e |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-564abd59010043ee9600d7ff5e7f711e2025-08-20T03:13:51ZengMDPI AGToxics2305-63042025-03-0113423710.3390/toxics13040237Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older AdultsXinliang Zheng0Wenxin Zhou1Zhuoying Jiang2Chan Ding3Minqian Feng4Yongxin Li5Fitri Kurniasari6Shuanghua Xie7Huadong Xu8School of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, ChinaDepartment of Environmental Health, Faculty of Public Health, University of Indonesia, Depok 16424, West Java, IndonesiaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, ChinaSchool of Public Health, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, Chinaα-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. This study investigated the relationship between urinary metal concentrations and serum α-Klotho levels using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2016 cycles. A total of 4071 adults aged 40 to 79 years were included in the analysis. After adjusting for potential confounders, positive associations were found between serum α-Klotho levels and barium (Ba), cesium (Cs), and molybdenum (Mo), while tungsten (W) and uranium (U) were negatively correlated with α-Klotho levels. The combined effects of multiple metals were further analyzed using the qgcomp model, which demonstrated a negative correlation between increased metal mixtures and serum α-Klotho levels. Specifically, U, total arsenic (t-As), W, cadmium (Cd), antimony (Sb), and lead (Pb) contributed to the reduction of α-Klotho levels, while Ba, Cs, dimethylarsinic acid (DMA), Mo, thallium (Tl), and cobalt (Co) were positively associated with α-Klotho levels. These findings suggest that exposure to certain metals, particularly in combination, may reduce serum α-Klotho levels, potentially accelerating aging processes. Further studies should investigate the underlying mechanisms responsible for these associations.https://www.mdpi.com/2305-6304/13/4/237α-Klothourinary metalsNHANESmetal mixturesaging biomarkers |
| spellingShingle | Xinliang Zheng Wenxin Zhou Zhuoying Jiang Chan Ding Minqian Feng Yongxin Li Fitri Kurniasari Shuanghua Xie Huadong Xu Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults Toxics α-Klotho urinary metals NHANES metal mixtures aging biomarkers |
| title | Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults |
| title_full | Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults |
| title_fullStr | Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults |
| title_full_unstemmed | Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults |
| title_short | Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults |
| title_sort | independent and combined associations of urinary heavy metal exposures with serum α klotho in middle aged and older adults |
| topic | α-Klotho urinary metals NHANES metal mixtures aging biomarkers |
| url | https://www.mdpi.com/2305-6304/13/4/237 |
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