Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review
Stiff-person syndrome (SPS) is a rare neurologic disease, most often caused by autoimmune process during which antibodies against glutamic acid decarboxylase (anti-GAD65) are synthesised. The main clinical symptoms, among which are axial and proximal leg muscle stiffness and painful spasms, are oft...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Vilnius University Press
2023-10-01
|
| Series: | Neurologijos seminarai |
| Subjects: | |
| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/33274 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593108845461504 |
|---|---|
| author | M. Nasvytis R. Kaladytė Lokominienė |
| author_facet | M. Nasvytis R. Kaladytė Lokominienė |
| author_sort | M. Nasvytis |
| collection | DOAJ |
| description |
Stiff-person syndrome (SPS) is a rare neurologic disease, most often caused by autoimmune process during which antibodies against glutamic acid decarboxylase (anti-GAD65) are synthesised. The main clinical symptoms, among which are axial and proximal leg muscle stiffness and painful spasms, are often provoked by external triggers. In addition to those, the disease presents with anxiety, phobias, and other psychiatric symptoms. The most notable SPS comorbidities include temporal lobe epilepsy and type 1 diabetes mellitus. In this article, we present a clinical case of a patient illustrating the course of the disease, diagnostic difficulties, and treatment options, all of which are discussed in the literature review.
|
| format | Article |
| id | doaj-art-56452758ca9e482db16939281250e24a |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-56452758ca9e482db16939281250e24a2025-01-20T18:22:08ZengVilnius University PressNeurologijos seminarai1392-30642424-59172023-10-01263 (93)10.29014/NS.2022.26.22Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature reviewM. Nasvytis0R. Kaladytė Lokominienė1Vilnius University, LithuaniaVilnius University, Lithuania Stiff-person syndrome (SPS) is a rare neurologic disease, most often caused by autoimmune process during which antibodies against glutamic acid decarboxylase (anti-GAD65) are synthesised. The main clinical symptoms, among which are axial and proximal leg muscle stiffness and painful spasms, are often provoked by external triggers. In addition to those, the disease presents with anxiety, phobias, and other psychiatric symptoms. The most notable SPS comorbidities include temporal lobe epilepsy and type 1 diabetes mellitus. In this article, we present a clinical case of a patient illustrating the course of the disease, diagnostic difficulties, and treatment options, all of which are discussed in the literature review. https://www.journals.vu.lt/neurologijos_seminarai/article/view/33274stiff-person syndromeantibodies against glutamic acid decarboxylaseplasmapheresis |
| spellingShingle | M. Nasvytis R. Kaladytė Lokominienė Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review Neurologijos seminarai stiff-person syndrome antibodies against glutamic acid decarboxylase plasmapheresis |
| title | Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review |
| title_full | Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review |
| title_fullStr | Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review |
| title_full_unstemmed | Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review |
| title_short | Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review |
| title_sort | successful treatment of stiff person syndrome with plasmapheresis case report and literature review |
| topic | stiff-person syndrome antibodies against glutamic acid decarboxylase plasmapheresis |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/33274 |
| work_keys_str_mv | AT mnasvytis successfultreatmentofstiffpersonsyndromewithplasmapheresiscasereportandliteraturereview AT rkaladytelokominiene successfultreatmentofstiffpersonsyndromewithplasmapheresiscasereportandliteraturereview |