Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study
The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2021/3825525 |
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| author | Amany A. Ghazy Mohammed Jayed Alenzi |
| author_facet | Amany A. Ghazy Mohammed Jayed Alenzi |
| author_sort | Amany A. Ghazy |
| collection | DOAJ |
| description | The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer. |
| format | Article |
| id | doaj-art-563d1052a4864ae0b62bb8472b6de3ac |
| institution | OA Journals |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-563d1052a4864ae0b62bb8472b6de3ac2025-08-20T02:04:58ZengWileyProstate Cancer2090-31112090-312X2021-01-01202110.1155/2021/38255253825525Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter StudyAmany A. Ghazy0Mohammed Jayed Alenzi1Department of Pathology (Microbiology and Immunology Unit), College of Medicine, Jouf University, Sakaka, Saudi ArabiaDepartment of Surgery, College of Medicine, Jouf University, Sakaka, Saudi ArabiaThe diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer.http://dx.doi.org/10.1155/2021/3825525 |
| spellingShingle | Amany A. Ghazy Mohammed Jayed Alenzi Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study Prostate Cancer |
| title | Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study |
| title_full | Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study |
| title_fullStr | Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study |
| title_full_unstemmed | Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study |
| title_short | Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study |
| title_sort | relevance of interleukins 6 and 8 single nucleotide polymorphisms in prostate cancer a multicenter study |
| url | http://dx.doi.org/10.1155/2021/3825525 |
| work_keys_str_mv | AT amanyaghazy relevanceofinterleukins6and8singlenucleotidepolymorphismsinprostatecanceramulticenterstudy AT mohammedjayedalenzi relevanceofinterleukins6and8singlenucleotidepolymorphismsinprostatecanceramulticenterstudy |