A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.

A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.

The increased incidence, high rates of mortality and few effective means of treatment of malignant melanoma, stimulate the search for new anti-tumor agents and therapeutic targets to control this deadly metastatic disease. In the present work the antitumor effect of arazyme, a natural bacterial-deri...

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Bibliographic Details
Main Authors: Felipe V Pereira, Carla A Ferreira-Guimarães, Thaysa Paschoalin, Jorge A B Scutti, Filipe M Melo, Luis S Silva, Amanda C L Melo, Priscila Silva, Manoela Tiago, Alisson L Matsuo, Luiz Juliano, Maria A Juliano, Adriana K Carmona, Luiz R Travassos, Elaine G Rodrigues
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096141&type=printable
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