Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis
Abstract Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high prevalence in China. Solasodine is a natural compound derived from the traditional herb that possess anticancer activity in various tumors, but its role in NPC remains unclear. Here, we demonstrated that solasodine potently sup...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-93834-4 |
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| author | Jing Wang DongHua Wang SiQing Ma BinSheng He JiaoYang Lu Zhen Guo |
| author_facet | Jing Wang DongHua Wang SiQing Ma BinSheng He JiaoYang Lu Zhen Guo |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Abstract Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high prevalence in China. Solasodine is a natural compound derived from the traditional herb that possess anticancer activity in various tumors, but its role in NPC remains unclear. Here, we demonstrated that solasodine potently suppressed NPC growth and induced cell death both in vitro and in vivo. Network pharmacology identified HMOX1 as a pivotal target of solasodine linked to ferroptosis. Solasodine triggered ferroptotic hallmarks, including mitochondrial cristae disruption, elevated Fe2⁺/ROS/MDA, depleted GSH, and dysregulated ferroptosis-related proteins (HMOX1/COX2↑, GPX4/MUC1/SLC40A1↓). Crucially, ferroptosis inhibitors (Fer-1/Lip-1), but not apoptosis, necroptosis, or autophagy inhibitors, rescued solasodine-induced cell death, confirming ferroptosis as the dominant mechanism. In conclusion, by applying network pharmacology accompanied with experimental validation, our study unveils solasodine as a novel ferroptosis inducer for NPC treatment. However, its therapeutic potential requires further validation in patient-derived models and clinical trials. |
| format | Article |
| id | doaj-art-5639d128f8a84b278ac978eee0ebf2ef |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-5639d128f8a84b278ac978eee0ebf2ef2025-08-20T03:48:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111710.1038/s41598-025-93834-4Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosisJing Wang0DongHua Wang1SiQing Ma2BinSheng He3JiaoYang Lu4Zhen Guo5Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical UniversitySchool of Nursing, Changsha Medical UniversityDepartment of Pharmacy, Hunan Chest HospitalHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical UniversityHunan Provincial Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical UniversityHunan Provincial Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical UniversityAbstract Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high prevalence in China. Solasodine is a natural compound derived from the traditional herb that possess anticancer activity in various tumors, but its role in NPC remains unclear. Here, we demonstrated that solasodine potently suppressed NPC growth and induced cell death both in vitro and in vivo. Network pharmacology identified HMOX1 as a pivotal target of solasodine linked to ferroptosis. Solasodine triggered ferroptotic hallmarks, including mitochondrial cristae disruption, elevated Fe2⁺/ROS/MDA, depleted GSH, and dysregulated ferroptosis-related proteins (HMOX1/COX2↑, GPX4/MUC1/SLC40A1↓). Crucially, ferroptosis inhibitors (Fer-1/Lip-1), but not apoptosis, necroptosis, or autophagy inhibitors, rescued solasodine-induced cell death, confirming ferroptosis as the dominant mechanism. In conclusion, by applying network pharmacology accompanied with experimental validation, our study unveils solasodine as a novel ferroptosis inducer for NPC treatment. However, its therapeutic potential requires further validation in patient-derived models and clinical trials.https://doi.org/10.1038/s41598-025-93834-4Nasopharyngeal carcinomaSolasodineFerroptosisNetwork pharmacologyCell death |
| spellingShingle | Jing Wang DongHua Wang SiQing Ma BinSheng He JiaoYang Lu Zhen Guo Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis Scientific Reports Nasopharyngeal carcinoma Solasodine Ferroptosis Network pharmacology Cell death |
| title | Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| title_full | Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| title_fullStr | Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| title_full_unstemmed | Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| title_short | Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| title_sort | solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis |
| topic | Nasopharyngeal carcinoma Solasodine Ferroptosis Network pharmacology Cell death |
| url | https://doi.org/10.1038/s41598-025-93834-4 |
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